Douralidou Despoina, Muñiz-Moris Laura, Solano Miguel, Mari Lorenzo
Neurology Department, The Ralph Veterinary Referral Centre, Marlow, UK.
Diagnostic Imaging Department, Veterios Veterinary Hospital, Madrid, Spain.
JFMS Open Rep. 2025 Aug 5;11(2):20551169251349741. doi: 10.1177/20551169251349741. eCollection 2025 Jul-Dec.
A 1-year-old male castrated Savannah cat presented with chronic recurrent lethargy, stiffness, right pelvic limb lameness and spinal hyperaesthesia. Eight months before referral, the cat was treated with prednisolone, remdesivir and a 1-week course of amoxicillin/clavulanic acid and marbofloxacin for suspected feline infectious peritonitis. Multiple recurrences were reported after initial presentation, and were treated with 1-week courses of amoxicillin/clavulanic acid. Neurological examination did not reveal further findings. Haematology showed neutrophilia/monocytosis. Spinal, limb and thoracic radiographs revealed irregular endplates and narrowing of T12-T13 and L7-S1 intervertebral disc spaces, metaphyseal lesions of multiple long bones with heterogeneous medullary bone and reduced corticomedullary distinction, and two areas of increased opacity in the left lung lobes. Feline leukaemia virus, feline immunodeficiency virus, toxoplasma serology and urine culture were negative. Blood culture was positive for species. Amoxicillin/clavulanic acid (20 mg/kg q12h) was started with clinical improvement, but no resolution of haematological/imaging changes. Relapse occurred 7 months into treatment. Blood culture showed , a suspected contaminant. Metronidazole (11 mg/kg q12h) was added based on sensitivity, with clinical improvement but relapse after discontinuation 4 months later. Neutrophilia and monocytosis were again identified, alongside hyperproteinaemia and globulinaemia. Recheck radiographs showed a worsening of the osteomyelitis but an improvement of the discospondylitis. species were cultured again from blood and bone biopsies. Marbofloxacin (4.5 mg/kg q24h) was initiated. At the 6-month follow-up, complete resolution of clinical and laboratory findings was documented alongside radiographic improvement of the previous lesions. Treatment was discontinued with no relapses over the 10-month follow-up.
To our knowledge, this is the first reported case of feline discospondylitis and osteomyelitis caused by species. Marbofloxacin, but not amoxicillin/clavulanic acid, led to resolution of the infection.
一只1岁已去势的萨凡纳猫出现慢性复发性嗜睡、僵硬、右后肢跛行和脊柱感觉过敏。转诊前8个月，该猫因疑似猫传染性腹膜炎接受泼尼松龙、瑞德西韦治疗，并使用阿莫西林/克拉维酸和马波沙星进行了为期1周的治疗。首次就诊后报告多次复发，并使用阿莫西林/克拉维酸进行了为期1周的治疗。神经学检查未发现其他异常。血液学检查显示中性粒细胞增多/单核细胞增多。脊柱、四肢和胸部X线片显示椎体终板不规则，T12 - T13和L7 - S1椎间盘间隙变窄，多根长骨的干骺端病变，骨髓骨不均匀，皮质骨与髓质骨分界不清，左肺叶有两个密度增加区域。猫白血病病毒、猫免疫缺陷病毒、弓形虫血清学检查和尿液培养均为阴性。血培养某菌种呈阳性。开始使用阿莫西林/克拉维酸（20mg/kg，每12小时一次）后临床症状有所改善，但血液学/影像学改变未得到缓解。治疗7个月后复发。血培养显示某菌，疑似污染物。根据药敏结果加用甲硝唑（11mg/kg，每12小时一次），临床症状改善，但停药4个月后复发。再次发现中性粒细胞增多和单核细胞增多，同时伴有高蛋白血症和球蛋白血症。复查X线片显示骨髓炎加重，但椎间盘炎有所改善。从血液和骨活检中再次培养出某菌种。开始使用马波沙星（4.5mg/kg，每24小时一次）。在6个月的随访中，临床和实验室检查结果完全恢复正常，之前病变的X线片也有所改善。治疗停止，在10个月的随访中无复发。
据我们所知，这是首例由某菌种引起的猫椎间盘炎和骨髓炎的报告病例。马波沙星而非阿莫西林/克拉维酸使感染得到缓解。
