Chen Liming, Manautou Jose E, Rasmussen Theodore P, Zhong Xiao-Bo
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Acta Pharm Sin B. 2019 Jul;9(4):659-674. doi: 10.1016/j.apsb.2019.01.007. Epub 2019 Jan 15.
Precision medicine is a rapidly-developing modality of medicine in human healthcare. Based on each patient׳s unique characteristics, more accurate dosages and drug selection can be made to achieve better therapeutic efficacy and less adverse reactions in precision medicine. A patient׳s individual parameters that affect drug transporter action can be used to develop a precision medicine guidance, due to the fact that therapeutic efficacy and adverse reactions of drugs can both be affected by expression and function of drug transporters on the cell membrane surface. The purpose of this review is to summarize unique characteristics of human breast cancer resistant protein (BCRP) and the genetic variability in the BCRP encoded gene in the development of precision medicine. Inter-individual variability of BCRP/ can impact choices and outcomes of drug treatment for several diseases, including cancer chemotherapy. Several factors have been implicated in expression and function of BCRP, including genetic, epigenetic, physiologic, pathologic, and environmental factors. Understanding the roles of these factors in controlling expression and function of BCRP is critical for the development of precision medicine based on BCRP-mediated drug transport.
精准医学是人类医疗保健领域中一种快速发展的医学模式。基于每位患者的独特特征，在精准医学中可以做出更准确的剂量选择和药物选择，以实现更好的治疗效果并减少不良反应。由于药物的治疗效果和不良反应都可能受到细胞膜表面药物转运体的表达和功能的影响，因此可以利用影响药物转运体作用的患者个体参数来制定精准医学指南。本综述的目的是总结人类乳腺癌耐药蛋白（BCRP）的独特特征以及BCRP编码基因在精准医学发展中的遗传变异性。BCRP的个体间变异性可能会影响包括癌症化疗在内的几种疾病的药物治疗选择和结果。BCRP的表达和功能涉及多个因素，包括遗传、表观遗传、生理、病理和环境因素。了解这些因素在控制BCRP表达和功能中的作用对于基于BCRP介导的药物转运的精准医学发展至关重要。
