关于液相色谱-高分辨率质谱法（LC-HRMS）优化与验证的数据，以确定速溶咖啡预混物中磷酸二酯酶5（PDE5）抑制剂的存在情况。
Data on the optimisation and validation of a liquid chromatography-high-resolution mass spectrometry (LC-HRMS) to establish the presence of phosphodiesterase 5 (PDE5) inhibitors in instant coffee premixes.
作者信息
Mohd Yusop Ahmad Yusri, Xiao Linda, Fu Shanlin
机构信息
Centre for Forensic Science, University of Technology Sydney, Ultimo, NSW, 2007 Australia.
Pharmacy Enforcement Division, Ministry of Health, Petaling Jaya, Selangor, 46200 Malaysia.
出版信息
Data Brief. 2019 Jul 8;25:104234. doi: 10.1016/j.dib.2019.104234. eCollection 2019 Aug.
This paper presents the data on the optimisation and validation of a liquid chromatography-high-resolution mass spectrometry (LC-HRMS) to establish the presence of phosphodiesterase 5 (PDE5) inhibitors and their analogues as adulterants in instant coffee premixes. The method development data covered chromatographic optimisation for better analyte separation and isomeric resolution, mass spectrometry optimisation for high sensitivity and sample preparation optimisation for high extraction recovery (RE) and low matrix effect (ME). The validation data covered specificity, linearity, range, accuracy, limit of detection, limit of quantification, precisions, ME, and RE. The optimisation and validation data presented here is related to the article: "Determination of phosphodiesterase 5 (PDE5) inhibitors in instant coffee premixes using liquid chromatography-high-resolution mass spectrometry (LC-HRMS)" Mohd Yusop et al., 2019.
本文介绍了关于液相色谱-高分辨率质谱法（LC-HRMS）优化和验证的数据，以确定磷酸二酯酶5（PDE5）抑制剂及其类似物作为速溶咖啡预混物中掺假物质的存在情况。方法开发数据涵盖了用于更好地分离分析物和异构体拆分的色谱优化、用于高灵敏度的质谱优化以及用于高萃取回收率（RE）和低基质效应（ME）的样品制备优化。验证数据涵盖了特异性、线性、范围、准确度、检测限、定量限、精密度、基质效应和萃取回收率。此处呈现的优化和验证数据与文章《使用液相色谱-高分辨率质谱法（LC-HRMS）测定速溶咖啡预混物中的磷酸二酯酶5（PDE5）抑制剂》相关，作者为Mohd Yusop等人，2019年。
Zotero 插件