胰岛素给药途径不影响1型糖尿病患者的25-羟基维生素D浓度：简要报告
Route of Insulin Does Not Influence 25-Hydroxyvitamin D Concentrations in Type 1 Diabetes: A Brief Report.
作者信息
van Dijk Peter R, Logtenberg Susan J J, Waanders Femke, Groenier Klaas H, van Goor Harry, Kleefstra Nanne, Bilo Henk J G
机构信息
Diabetes Centre, Isala, Zwolle, Netherlands.
Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
出版信息
J Endocr Soc. 2019 Jun 17;3(8):1541-1544. doi: 10.1210/js.2019-00105. eCollection 2019 Aug 1.
Abstract
The increased prevalence of vitamin D [25(OH)D] deficiency in type 1 diabetes mellitus (T1DM) may be related to low insulin levels in the hepatic portal venous system. In this prospective matched-control study, we demonstrate that long-term intraperitoneal insulin does not influence 25(OH)D concentrations in patients with T1DM as compared with subcutaneous insulin administration.
摘要
1型糖尿病（T1DM）患者中维生素D [25(OH)D] 缺乏症患病率的增加可能与肝门静脉系统中胰岛素水平较低有关。在这项前瞻性配对对照研究中，我们证明，与皮下注射胰岛素相比，长期腹腔内注射胰岛素对T1DM患者的25(OH)D浓度没有影响。
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