Tahlan Sumit, Kumar Sanjiv, Narasimhan Balasubramanian
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001 India.
BMC Chem. 2019 Feb 4;13(1):18. doi: 10.1186/s13065-019-0521-y. eCollection 2019 Dec.
Benzimidazole is a heterocyclic moiety whose derivatives are present in many of the bioactive compounds and posses diverse biological and clinical applications. Benzimidazole agents are the vital pharmacophore and privileged sub-structures in chemistry of medicine. They have received much interest in drug discovery because benzimidazoles exhibited enormous significance. So attempts have been made to create repository of molecules and evaluate them for prospective inherent activity. They are extremely effective both with respect to their inhibitory activity and favorable selectivity ratio.
Benzimidazole is most promising category of bioactive heterocyclic compound that exhibit a wide variety of biological activities in medicinal field. The present review only focus on antimicrobial activity of reported benzimidazole derivatives may serve as valuable source of information for researchers who wish to synthesize new molecules of benzimidazole nucleus which have immense potential to be investigated for newer therapeutic possibilities.
苯并咪唑是一种杂环部分，其衍生物存在于许多生物活性化合物中，并具有多种生物学和临床应用。苯并咪唑类药物是药物化学中至关重要的药效基团和优势亚结构。它们在药物发现中备受关注，因为苯并咪唑具有巨大的意义。因此，人们已尝试建立分子库并评估它们的潜在内在活性。它们在抑制活性和良好的选择性比率方面都极其有效。
苯并咪唑是最有前景的生物活性杂环化合物类别，在医学领域展现出广泛的生物活性。本综述仅关注已报道的苯并咪唑衍生物的抗菌活性，可为希望合成具有巨大潜力以待探索新治疗可能性的苯并咪唑核新分子的研究人员提供有价值的信息来源。
