Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Centre of Molecular and Macromolecular Studies, Polish Academy of Science, Sienkiewicza 112, 90-363 Lodz, Poland.
Int J Mol Sci. 2023 Feb 7;24(4):3319. doi: 10.3390/ijms24043319.
Three new crystal structures of 1-benzo[]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs.
测定了三个 1-苯并[]咪唑衍生物的新晶体结构。在这些化合物的结构中，观察到了相同的氢键系统 C(4)。固态 NMR 用于测试获得样品的质量。通过检查它们的选择性，对所有这些化合物进行了体外抗革兰氏阳性菌和革兰氏阴性菌的抗菌活性以及抗真菌活性测试。ADME 计算表明，这些化合物可以作为潜在药物进行测试。
