Synthesis of thiophene derivatives and their anti-microbial, antioxidant, anticorrosion and anticancer activity.

BACKGROUND

A new series of thiophene analogues was synthesized and checked for their in vitro antibacterial, antifungal, antioxidant, anticorrosion and anticancer activities.

RESULTS

A series of ethyl-2-(substituted benzylideneamino)-4,5,6,7-tetrahydrobenzo[]thiophene-3-carboxylate derivatives were synthesized by using Gewald synthesis and their structures were confirmed by FTIR, MS and H-NMR. The synthesized compounds were further evaluated for their in vitro biological potentials i.e. antimicrobial activity against selected microbial species using tube dilution method, antiproliferative activity against human lung cancer cell line (A-549) by sulforhodamine B assay, antioxidant activity by using DPPH method and anticorrosion activity by gravimetric method.

CONCLUSION

Antimicrobial screening results showed that compound was the most potent antibacterial agent against , and having MIC value 0.81 µM/ml and compound also displayed excellent antifungal activity against both and (MIC = 0.91 µM/ml) when compared with cefadroxil (antibacterial) and fluconazole (antifungal) as standard drug. The antioxidant screening results indicated that compound and exhibited excellent antioxidant activity with IC values and respectively when compared with the ascorbic acid as standard drug. Anticorrosion screening results indicated that compound showed more anticorrosion efficiency (97.90%) with low corrosion rate. Results of anticancer screening indicated that compound showed effective cytotoxic activity against human lung cancer cell line (A-549) at dose of 10 M when compared with adriamycin as standard.