1-[1,2,4-三唑-3-基]和1-[1,3,4-噻二唑-2-基]-3-甲硫基-6,7-二氢苯并[c]噻吩-4(5H)酮的合成及其抗菌活性
Synthesis and antibacterial activity of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones.
作者信息
Tehranchian Sara, Akbarzadeh Tahmineh, Fazeli Mohammad Reza, Jamalifar Hossein, Shafiee Abbas
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1023-5. doi: 10.1016/j.bmcl.2004.12.039.
A series of 1-[1,2,4-triazol-3-yl] and 1-[1,3,4-thiadiazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones were synthesized and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a good activity against Staphylococcus aureus, S. epidermidis and Bacillus subtilis.
合成了一系列1-[1,2,4-三唑-3-基]和1-[1,3,4-噻二唑-2-基]-3-甲硫基-6,7-二氢苯并[c]噻吩-4(5H)酮，并进行测试以证明其体外抗菌活性。其中一些化合物对金黄色葡萄球菌、表皮葡萄球菌和枯草芽孢杆菌表现出良好的活性。
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