Laboratory of Photochemistry, Department of Drug Science, Viale Andrea Doria 6, 95125, Catania, Italy.
Drug Delivery Laboratory, Department of Pharmacy, University of Napoli Federico II, Via Domenico Montesano 49, 80131, Napoli, Italy.
J Mater Chem B. 2019 Sep 14;7(34):5257-5264. doi: 10.1039/c9tb00699k. Epub 2019 Aug 6.
In this contribution we report the design, preparation, and physico-chemical, photophysical and photochemical characterization of photoactivatable microemulsions (MEs) based on Labrasol®, isopropanol and Lauroglycol® FCC as a surfactant, co-surfactant and oily phase, respectively. The MEs co-incorporate, in their oil phase, two lipophilic guests such as a red emitting singlet oxygen (O) photosensitizer (PS) and a tailored green emitting nitric oxide (NO) photodonor (NOPD). These two chromofluorogenic units absorb in different spectral windows of the visible range, and their individual photophysical and photochemical properties are well-conserved when co-entrapped in the microemulsions. These features permit the PS and NOPD to operate either individually or in tandem resulting in (i) red, green or both fluorescence emission, (ii) photogeneration of cytotoxic O, NO or both and (iii) amplified photobactericidal action against Staphylococcus aureus due to the combined effect of these two antibacterial agents.
在本研究中，我们报告了基于 Labrasol®、异丙醇和 Lauroglycol® FCC 的光活化微乳液（MEs）的设计、制备以及物理化学、光物理和光化学特性。这些 MEs 在油相中共同包含两种亲脂性客体，如红色发射单线态氧（O）光敏剂（PS）和定制的绿色发射一氧化氮（NO）光供体（NOPD）。这两个发色荧光团在可见光的不同光谱窗口中吸收，并且当它们共包封在微乳液中时，其各自的光物理和光化学性质得到很好的保留。这些特性允许 PS 和 NOPD 单独或串联操作，从而导致（i）红色、绿色或两者的荧光发射，（ii）细胞毒性 O、NO 或两者的光生成，以及（iii）由于这两种抗菌剂的协同作用，对金黄色葡萄球菌的增强光杀菌作用。
