Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology (INT), Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany.
Laboratoire National des Champs Magnétiques Intenses, LNCMI-CNRS (UPR3228), EMFL, Univ. Grenoble Alpes, INSA Toulouse, Univ. Toulouse Paul Sabatier, B.P. 166, 38042, Grenoble Cedex, France.
Dalton Trans. 2019 Nov 7;48(41):15597-15604. doi: 10.1039/c9dt02052g. Epub 2019 Aug 6.
Paramagnetic polyoxometalates [RECoGeWO(OH)(OH)] (Rare Earth (RE): Gd, Dy, Eu, and Y) are of special interest with regard to their application as alternative contrast agents in non-human magnetic resonance imaging which is increasingly used in materials science and process engineering. This class of new paramagnetic materials promises detailed findings in the magnetic resonance images due to their rather large total electron spin on the one hand, i.e. large, field-dependent relaxivities up to the highest magnetic fields, and due to their relatively large cluster sizes with an impact on adsorption and penetration on the other hand. Apart from the magnetic field dependence, the sensitivity of relaxivities to motional correlation times will be shown for these polyoxometalates which is a prerequisite for modelling and understanding the physical behaviour of this new class of polyoxometalates in MRI. Also for the qualitative and quantitative interpretation of MR images, the knowledge of transverse and longitudinal relaxivities of the paramagnetic clusters in a given environment is mandatory. Examples considered in this publication are proteins in milk fractionation, the deposit of which was measured by MRI.
具有顺磁性的多金属氧酸盐 [RECoGeWO(OH)(OH)]（稀土 (RE)：Gd、Dy、Eu 和 Y）在非人类磁共振成像中作为替代对比剂的应用特别令人关注，因为磁共振成像在材料科学和过程工程中的应用越来越广泛。由于这类新型顺磁材料的总电子自旋较大，一方面具有较大的场依赖性弛豫率，可达最高磁场，另一方面由于其相对较大的簇尺寸对吸附和穿透有影响，因此有望在磁共振图像中获得详细的结果。除了磁场依赖性之外，还将展示这些多金属氧酸盐的弛豫率对运动相关时间的敏感性，这是对这种新类多金属氧酸盐在 MRI 中的物理行为进行建模和理解的前提条件。对于磁共振图像的定性和定量解释，在给定环境中顺磁团簇的横向弛豫率和纵向弛豫率的知识也是必需的。本文考虑的例子是牛奶分离中的蛋白质，其沉积物通过 MRI 进行了测量。
