Swiss Blood Stem Cells, Swiss Transfusion SRC Ltd, Bern, Switzerland.
Eur J Haematol. 2019 Oct;103(4):426-432. doi: 10.1111/ejh.13307. Epub 2019 Aug 22.
Planning new hematopoietic stem cell (HSC) donor recruitment strategies requires a sound understanding of the factors underlying donor selection, especially considering HLA-matching criteria.
A total of 182 consecutive workups of Swiss donors performed from 2014 to 2017 were analyzed for HLA match level, locus disparities, number of potentially 10/10 matched donors in the international database, donor ranking on the lists, donor date of registration, age, ABO, CMV, gender matching, patient genotype frequency, and country performing the search.
Matching status of the selected donors was 10/10 for 38.5%, 10-12/12 for 35.1%, and 8-9/10 for 26.4% donors, without differences in average donor age in the three categories. HLA-A and -C mismatches were most frequent and -DRB1 very rare. 8.2% patients were matched for HLA-DPB1 (12/12). ABO matching was 46.3%, and CMV matching was 59.1%. Based on "HaploStat"-derived genotype frequencies, 50.3% patients belonged to the "good," 38.5% to the "fair," and 11.2% to the "poor" search prognosis categories. 37.9% of transplants were gender-mismatched, and 42.3% of donors were female.
HLA typing quality (high resolution, all loci typed), great diversity of haplotypes and donor age are main factors impacting the selection of Swiss donors, while gender and ABO matching seem to be of secondary importance.
规划新的造血干细胞（HSC）供者招募策略需要对供者选择背后的因素有深入的了解，尤其是考虑到 HLA 匹配标准。
分析了 2014 年至 2017 年期间进行的 182 例连续瑞士供者的检查，以分析 HLA 匹配水平、基因座差异、国际数据库中潜在的 10/10 匹配供者数量、供者名单上的排名、供者注册日期、年龄、ABO、CMV、性别匹配、患者基因型频率以及进行搜索的国家。
所选供者的匹配状态为 10/10 的占 38.5%，10-12/12 的占 35.1%，8-9/10 的占 26.4%，三个类别中供者的平均年龄没有差异。HLA-A 和 -C 错配最常见，-DRB1 非常罕见。8.2%的患者 HLA-DPB1 匹配（12/12）。ABO 匹配率为 46.3%，CMV 匹配率为 59.1%。基于“HaploStat”衍生的基因型频率，50.3%的患者属于“良好”搜索预后类别，38.5%属于“中等”，11.2%属于“较差”。37.9%的移植存在性别不匹配，42.3%的供者为女性。
HLA 分型质量（高分辨率，所有基因座分型）、单倍型多样性和供者年龄是影响瑞士供者选择的主要因素，而性别和 ABO 匹配似乎是次要因素。
