Histogram analysis of diffusion kurtosis imaging based on whole-volume images of breast lesions.

BACKGROUND

Breast diffusion kurtosis imaging (DKI) is a novel MRI technique to assess breast cancer but the effectivity still remains to be improved.

PURPOSE

To investigate the performance of whole-volume histogram parameters derived from a DKI model for differentiating benign and malignant breast lesions.

STUDY TYPE

Retrospective.

POPULATION

In all, 120 patients with breast lesions (62 malignant, 58 benign).

SEQUENCE

DKI sequence with seven b-values (0, 500, 1000, 1500, 2000, 2500, and 3000 s/mm ) and DWI sequence with two b-values (0 and 1000 s/mm ) on 3.0T MRI.

ASSESSMENT

Histogram parameters of the DKI model (K and D) and the DWI model (ADC), including the minimum, maximum, mean, percentile values (25th, 50th, 75th, and 95th), standard deviation, kurtosis and skewness, were calculated by two radiologists for the whole lesion volume.

STATISTICAL TESTS

Student's t-test was used to compare malignant and benign lesions. The diagnostic performances were evaluated by receiver operating characteristic (ROC) analysis.

RESULTS

K , D , and ADC had the highest area under the curve (AUC) (0.875, 0.830, and 0.847, respectively), sensitivity (85.5%, 74.2%, and 77.4%, respectively), and accuracy (85.0%, 79.2%, and 81.7%, respectively) in their individual histogram parameter groups, and K was found to outperform D and ADC . ADC histogram parameters (from ADC to ADC ) were significantly lower than D histogram parameters in all groups.

DATA CONCLUSION

K , D , and ADC were found to be better metrics than the corresponding average values for differentiating benign from malignant tumors. Histogram parameters derived from the DKI model provided more information and had better diagnostic performance than ADC parameters derived from the DWI model.

LEVEL OF EVIDENCE

3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:627-634.