Department of Gynecologic Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China.
Cancer Med. 2019 Sep;8(12):5425-5430. doi: 10.1002/cam4.2435. Epub 2019 Aug 6.
In recent years, the incidence of gynecological malignant tumors during pregnancy has increased, mainly due to the increased number of old age pregnancy. The most common gynecological malignant tumors in pregnancy are cervical cancer, accounting for 71.6%, followed by ovarian malignant tumors, accounting for 7.0%. The incidence of cervical cancer in pregnancy is itself not very high, and the symptoms are easily confused with other diseases in pregnancy. During pregnancy, gynecological examination is limited, and therefore, the rate of misdiagnosis is higher. The treatment of cervical cancer during pregnancy is related to many factors, such as tumor size, pathological type, period of gestation, lymph node involvement, and patients' willingness to maintain pregnancy. As a reason of these factors, it is difficult to determine the optimal treatment. This article reviews the research progress on the diagnosis and treatment principles of cervical cancer in pregnancy, in order to strike a balance between effective treatment of tumors and protection of fetal health, and avoid delays in treatment and preterm delivery.
近年来,妊娠期妇科恶性肿瘤的发病率有所增加,主要与高龄妊娠的人数增加有关。妊娠期最常见的妇科恶性肿瘤是宫颈癌,占 71.6%,其次是卵巢恶性肿瘤,占 7.0%。妊娠期宫颈癌的发病率本身并不高,症状容易与妊娠其他疾病混淆。妊娠期妇科检查受限,因此误诊率较高。妊娠期宫颈癌的治疗与肿瘤大小、病理类型、妊娠时期、淋巴结受累以及患者维持妊娠的意愿等诸多因素有关。由于这些因素的存在,很难确定最佳的治疗方案。本文就妊娠期宫颈癌的诊治原则的研究进展进行综述,旨在平衡肿瘤的有效治疗与胎儿健康的保护,避免治疗延误和早产。