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亚洲人群研究:前列腺尿道悬吊术治疗良性前列腺增生症的临床疗效评估

Evaluation of Clinical Outcomes of Prostatic Urethral Lift for Benign Prostatic Hyperplasia: An Asian Population Study.

作者信息

Kim Jeong Ho, Lee Ki Soo, Kim Tae Hyo

机构信息

Department of Urology, Dongnam Institute of Radiological and Medical Sciences, Cancer Center, Busan, Korea.

Department of Urology, Dong-A University College of Medicine, Busan, Korea.

出版信息

World J Mens Health. 2020 Jul;38(3):338-344. doi: 10.5534/wjmh.190015. Epub 2019 Jul 30.

Abstract

PURPOSE

This study aimed to assess the clinical outcomes of prostatic urethral lift in Korean patients with bothersome lower urinary tract symptoms due to benign prostatic hyperplasia (BPH).

MATERIALS AND METHODS

Thirty-two men with symptomatic BPH were consecutively treated in a tertiary care center in Korea. To be included in the present analysis, patients had to meet the following criteria: age ≥50 years, International Prostatic Symptom Score (IPSS) >12, and prostate volume between 30 mL and 80 mL. Patients were evaluated up to a median follow-up period of 1 year post-procedure. The primary outcomes included symptom relief, improvement of quality of life (QOL), and preservation of sexual function.

RESULTS

All procedures were finished with a mean of 2.2 implants without any serious complication. The numbers of patients diagnosed with diabetes mellitus, hypertension, and ischemic heart disease were 16 (50.0%), 24 (75.0%), and 9 (28.1%), respectively. Patients experienced symptom relief by 1 week that was sustained for 12 months. The mean IPSS, QOL, and maximum flow rate improved to 43%, 70%, and 25% by 1 week, and to 41%, 60%, and 32% by 12 months (p<0.001), respectively. There were no occurrences of early urge incontinence, retrograde ejaculation, or erectile dysfunction. Patient-reported adverse events were mild and transient.

CONCLUSIONS

Prostatic urethral lift is a safe and effective treatment for BPH in the Asian population. This treatment is minimally invasive, can be performed under local anesthesia, and may be an appropriate method for fragile patients.

摘要

目的

本研究旨在评估前列腺尿道悬吊术对因良性前列腺增生(BPH)导致下尿路症状困扰的韩国患者的临床疗效。

材料与方法

32例有症状的BPH男性患者在韩国一家三级医疗中心接受了连续治疗。纳入本分析的患者必须符合以下标准:年龄≥50岁,国际前列腺症状评分(IPSS)>12,前列腺体积在30 mL至80 mL之间。对患者进行了长达术后1年的中位随访评估。主要结局包括症状缓解、生活质量(QOL)改善以及性功能保留。

结果

所有手术平均植入2.2个假体完成,无任何严重并发症。诊断为糖尿病、高血压和缺血性心脏病的患者人数分别为16例(50.0%)、24例(75.0%)和9例(28.1%)。患者在1周时出现症状缓解,并持续了12个月。平均IPSS、QOL和最大尿流率在1周时分别改善了43%、70%和25%,在12个月时分别改善了41%、60%和32%(p<0.001)。未发生早期急迫性尿失禁、逆行射精或勃起功能障碍。患者报告的不良事件轻微且短暂。

结论

前列腺尿道悬吊术是亚洲人群BPH的一种安全有效的治疗方法。该治疗微创,可在局部麻醉下进行,可能是体弱患者的合适治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ad5/7308227/33534cbab7d6/wjmh-38-338-g001.jpg

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