终端酰胺，一种新的神经酰胺和其他植物成分从 H. 佩里的根和他们的生物活性。
Terminaliamide, a new ceramide and other phytoconstituents from the roots of H. Perrier and their biological activities.
机构信息
Unité Microbiologie, Chimie Bioorganique et Macromoléculaire, Département R3D, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
出版信息
Nat Prod Res. 2021 Apr;35(8):1313-1322. doi: 10.1080/14786419.2019.1647425. Epub 2019 Aug 6.
Terminaliamide (), a new ceramide was isolated from the roots of H. Perrier () along with 4 known compounds (-). The structures of the compounds were elucidated using 1D and 2D NMR spectroscopy analysis and mass spectrometry. Compound exhibited moderated antibacterial activity towards with MIC value of 62.5 μg/mL. The crude MeOH extract (TMr) highly reduced growth with an IC value of 10.11 μg/mL, while hexane fraction (F1) highly reduced growth with an IC value of 5.60 µg/mL. All tested samples presented little or no cytotoxicity on HeLa cell line. The present work confirms that is medicinally important and may be used effectively as an antimicrobial, an antiplasmodial and an antitrypanosomial with promising therapeutic index.
从 H. Perrier 的根部分离得到一种新的神经酰胺，命名为端粒酰胺（），同时还分离得到 4 种已知化合物（-）。采用 1D 和 2D NMR 光谱分析和质谱法确定了化合物的结构。化合物 对 表现出中等强度的抗菌活性，MIC 值为 62.5μg/mL。粗甲醇提取物（TMr）对 生长的抑制作用较强，IC 值为 10.11μg/mL，而正己烷部分（F1）对 生长的抑制作用较强，IC 值为 5.60μg/mL。所有测试的样品对 HeLa 细胞系几乎没有或没有细胞毒性。本研究证实 具有重要的药用价值，可有效用作抗菌、抗疟原虫和抗锥虫药物，具有良好的治疗指数。
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