Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Expert Rev Neurother. 2019 Dec;19(12):1211-1218. doi: 10.1080/14737175.2019.1650642. Epub 2019 Aug 6.
:Many different types of surgical procedures are available for patients with drug-resistant epilepsy. MRI-guided laser interstitial thermal therapy is a stereotactic procedure with the potential to provide excellent seizure outcomes, while minimizing surgical approach related complications.:This review will cover the role of MRgLITT in the treatment of multiple facets of epilepsy including temporal lobe epilepsy, nodular heterotopias, hypothalamic hamartomas, as well as corpus Callosotomy.:The development of magnetic resonance thermography has advanced continuous monitoring of thermal tissue destruction of pathological tissue in near real-time to allow for individualized neurological care for a person with epilepsy. Overall the results of MRgLITT appear similar to larger open forms of epilepsy surgery though with the promise of a safer side-effect profile. To improve this technique we must develop intraoperative biomarkers of procedural success, and develop tools to improve our patient selection.
:有许多不同类型的手术程序可供耐药性癫痫患者选择。磁共振引导激光间质热疗是一种立体定向手术，有可能提供出色的癫痫发作结果，同时将手术相关并发症降至最低。:本篇综述将涵盖 MRgLITT 在治疗多种癫痫的作用，包括颞叶癫痫、结节性异位、下丘脑错构瘤，以及胼胝体切开术。:磁共振热成像的发展使我们能够实时监测病理性组织的热组织破坏，为癫痫患者提供个性化的神经护理。总体而言，MRgLITT 的结果与更大规模的开放性癫痫手术相似，但具有更安全的副作用特征。为了改进这项技术，我们必须开发术中程序成功的生物标志物，并开发工具来改善我们的患者选择。
