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大麻与癫痫

Cannabis and Epilepsy.

机构信息

Department of Neurology, UTSW Epilepsy Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

出版信息

J Dual Diagn. 2020 Jan-Mar;16(1):75-82. doi: 10.1080/15504263.2019.1645372. Epub 2019 Aug 6.

DOI:10.1080/15504263.2019.1645372
PMID:31385740
Abstract

In recent years, the use of cannabidiol in the treatment of refractory epilepsy has been increasingly investigated and has been gaining public support as a novel way to treat these disorders. Marijuana has been used for medical purposes for thousands of years, and a lot of research has been conducted over the last several decades into the chemistry and pharmacology of marijuana and its many compounds, including cannabidiol. Using PubMed, we performed a review of the literature regarding the history of cannabinoid use in treating epilepsy. There are historical and recent scientific developments that support the use of cannabidiol in rare severe epilepsy syndromes.

摘要

近年来,大麻二酚在治疗难治性癫痫中的应用越来越受到关注,并作为一种治疗这些疾病的新方法得到了公众的支持。大麻已经被用于医疗目的几千年了,过去几十年里,人们对大麻及其许多化合物的化学和药理学进行了大量研究,包括大麻二酚。我们使用 PubMed 对有关大麻素治疗癫痫的文献进行了回顾。有一些历史和近期的科学发展支持在罕见的严重癫痫综合征中使用大麻二酚。

相似文献

1
Cannabis and Epilepsy.大麻与癫痫
J Dual Diagn. 2020 Jan-Mar;16(1):75-82. doi: 10.1080/15504263.2019.1645372. Epub 2019 Aug 6.
2
The Utility of Cannabidiol in the Treatment of Refractory Epilepsy.大麻二酚在难治性癫痫治疗中的效用。
Clin Pharmacol Ther. 2017 Feb;101(2):182-184. doi: 10.1002/cpt.441. Epub 2016 Sep 29.
3
Cannabis for the Treatment of Epilepsy: an Update.大麻治疗癫痫:最新进展。
Curr Neurol Neurosci Rep. 2018 Sep 8;18(11):73. doi: 10.1007/s11910-018-0882-y.
4
Cannabis, cannabidiol, and epilepsy--from receptors to clinical response.大麻、大麻二酚与癫痫——从受体到临床反应
Epilepsy Behav. 2014 Dec;41:277-82. doi: 10.1016/j.yebeh.2014.08.135. Epub 2014 Oct 1.
5
The Pharmacological Basis of Cannabis Therapy for Epilepsy.大麻治疗癫痫的药理学基础。
J Pharmacol Exp Ther. 2016 Apr;357(1):45-55. doi: 10.1124/jpet.115.230151. Epub 2016 Jan 19.
6
Cannabis-based products for pediatric epilepsy: An updated systematic review.基于大麻的儿科癫痫治疗产品:一项更新的系统评价。
Seizure. 2020 Feb;75:18-22. doi: 10.1016/j.seizure.2019.12.006. Epub 2019 Dec 9.
7
Cannabis and Endocannabinoid Signaling in Epilepsy.大麻与癫痫中的内源性大麻素信号传导
Handb Exp Pharmacol. 2015;231:285-316. doi: 10.1007/978-3-319-20825-1_10.
8
Marijuana Use in Epilepsy: The Myth and the Reality.癫痫患者使用大麻:神话与现实
Curr Neurol Neurosci Rep. 2015 Oct;15(10):65. doi: 10.1007/s11910-015-0586-5.
9
Cannabis based medicines and cannabis dependence: A critical review of issues and evidence.基于大麻的药物和大麻依赖:问题和证据的批判性回顾。
J Psychopharmacol. 2021 Jul;35(7):773-785. doi: 10.1177/0269881120986393. Epub 2021 Feb 17.
10
Introduction to Cannabis Special Issue.大麻特刊引言。
J Dual Diagn. 2020 Jan-Mar;16(1):1-2. doi: 10.1080/15504263.2019.1708551. Epub 2020 Jan 6.

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