Organic Chemistry Laboratory, University of Bayreuth, 95447, Bayreuth, Germany.
Chem Biodivers. 2019 Sep;16(9):e1900366. doi: 10.1002/cbdv.201900366. Epub 2019 Aug 30.
The natural polyisoprenylated benzophenone derivatives garcinol and isogarcinol are secondary plant metabolites isolated from various Garcinia species including Garcinia indica. This review takes stock of the recent chemical and biological research into these interesting natural compounds over the last five years. New biological sources and chemical syntheses are discussed followed by new insights into the activity of garcinol and isogarcinol against cancer, pathogenic bacteria, parasite infections and various inflammatory diseases.
天然多异戊烯基二苯甲酮衍生物 garcinol 和异 garcinol 是从包括 Garcinia indica 在内的多种 Garcinia 物种中分离出来的植物次生代谢物。本综述总结了过去五年中对这些有趣的天然化合物的最新化学和生物学研究。讨论了新的生物来源和化学合成方法，以及 garcinol 和异 garcinol 对癌症、病原菌、寄生虫感染和各种炎症性疾病的活性的新见解。
