Beudel Martijn, Oterdoom D L Marinus, van Egmond Martje E, van Laar Teus, de Koning-Tijssen Marina A J, van Dijk J Marc C
Amsterdam UMC, locatie AMC, afd. Neurologie, Amsterdam.
Contact: M. Beudel (
Ned Tijdschr Geneeskd. 2019 Aug 6;163:D3758.
Deep brain stimulation (DBS) is a treatment which uses high-frequency electric stimulation to suppress pathological brain activity. DBS has been applied for over 30 years now, particularly in patients with severe movement disorders, such as Parkinson's disease, dystonia and tremor. Although there is clearly scientific evidence for the effectiveness of DBS in these three movement disorders, the effect size of the treatment remains limited. Furthermore, DBS is not curative and can only be applied in a select subset of patients. In this article, we discuss the key indications and contraindications for DBS, and the outcomes achieved when it is applied in the aforementioned movement disorders. We discuss the most notable controversies and new developments in the field of deep brain stimulation, in order to offer referrers and fellow healthcare professionals an accessible introduction to this mode of therapy.
深部脑刺激（DBS）是一种利用高频电刺激来抑制病理性脑活动的治疗方法。DBS已应用了30多年，尤其适用于患有严重运动障碍的患者，如帕金森病、肌张力障碍和震颤。尽管有明确的科学证据表明DBS对这三种运动障碍有效，但治疗的效果大小仍然有限。此外，DBS不能治愈疾病，且只能应用于特定的患者亚组。在本文中，我们讨论了DBS的关键适应症和禁忌症，以及将其应用于上述运动障碍时所取得的结果。我们还讨论了深部脑刺激领域最显著的争议和新进展，以便为转诊医生和其他医疗专业人员提供对这种治疗方式的易懂介绍。
