Gris J C, Schved J F, Tousch D, Hereil S, Feugeas O
Laboratoire d'Hématologie et Immunologie, CHRU de Nîmes, France.
Nouv Rev Fr Hematol (1978). 1988;30(3):143-7.
We have studied IgG F(ab')2 fractions in the plasma from a patient during spontaneous remission from lupus anticoagulant (LAC). Fractions from the remission period inhibited the LAC activity of preremission fractions, as evaluated by in vitro coagulation tests. Idiotypic/anti-idiotypic interactions were demonstrated by affinity chromatography. The same results were obtained with IgG F(ab')2 from pooled normal plasma. This enables us to treat the LAC relapse in this patient with purified recurrent anti-idiotypic determinant antibodies extracted from normal plasma.
我们研究了一名狼疮抗凝物（LAC）自发缓解期患者血浆中的IgG F(ab')2片段。通过体外凝血试验评估，缓解期的片段抑制了缓解前期片段的LAC活性。通过亲和层析证明了独特型/抗独特型相互作用。从混合正常血浆中提取的IgG F(ab')2也得到了相同的结果。这使我们能够用从正常血浆中提取的纯化复发抗独特型决定簇抗体治疗该患者的LAC复发。
