遗传性全面性癫痫的视盘周围视网膜神经纤维层变薄。
Peripapillary retinal nerve fibre layer thinning in genetic generalized epilepsy.
机构信息
Epilepsy-EEG Unit, Hospital Universitario 12 de Octubre, Madrid, Spain; Department of Neurology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Department of Neurology, Hospital Universitario 12 de Octubre, Madrid, Spain.
出版信息
Seizure. 2019 Oct;71:201-206. doi: 10.1016/j.seizure.2019.07.022. Epub 2019 Aug 1.
PURPOSE
The purpose of this study was to compare the peripapillary retinal nerve fibre layer (RNFL) between patients with genetic generalized epilepsy (GGE) and healthy controls.
METHODS
This prospective observational study was conducted on adults aged 18-60 years. The study group comprised 26 consecutive patients who met the inclusion criteria and 26 healthy age- and sex-matched healthy adults. Peripapillary RNFL thickness was measured by spectral domain optical coherence tomography.
RESULTS
The average peripapillary RNFL thickness was significantly thinner for GGE patients (98.61 μm) than for healthy controls (104.77 μm) (p = 0.016). Similar results were obtained for the left eye. The peripapillary RFNL thickness of all quadrants was lower for GGE patients than for healthy controls, but it was significant only in the superior (p = 0.009) and inferior (p = 0.024) quadrants for both eyes.
CONCLUSIONS
Our results suggest that the peripapillary RNFL is significantly thinner in GGE patients than in healthy participants. We concluded that this microstructural feature might be an intrinsic feature of GGE.
目的
本研究旨在比较遗传性全面性癫痫（GGE）患者与健康对照者的视盘周围视网膜神经纤维层（RNFL）。
方法
这是一项前瞻性观察性研究，纳入了年龄在 18-60 岁之间的成年人。研究组包括 26 名符合纳入标准的连续 GGE 患者和 26 名年龄和性别匹配的健康成年人。采用频域光学相干断层扫描测量视盘周围 RNFL 厚度。
结果
GGE 患者的平均视盘周围 RNFL 厚度（98.61μm）明显薄于健康对照组（104.77μm）（p=0.016）。左眼也得到了类似的结果。GGE 患者的所有象限的视盘周围 RFNL 厚度均低于健康对照组，但仅在双眼的上象限（p=0.009）和下象限（p=0.024）具有统计学意义。
结论
我们的研究结果表明，GGE 患者的视盘周围 RNFL 明显比健康参与者薄。我们得出结论，这种微观结构特征可能是 GGE 的内在特征。
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