Cancer Discov. 2019 Sep;9(9):1152. doi: 10.1158/2159-8290.CD-NB2019-092. Epub 2019 Aug 6.
Researchers have developed a KRAS inhibitor, BI-2852, that inhibits ERK phosphorylation and reduces proliferation of KRAS-mutant cancer cells. A drug based on the molecule may be effective in patients who don't respond to the KRAS inhibitors currently in clinical trials.
研究人员开发了一种 KRAS 抑制剂 BI-2852,它可以抑制 ERK 磷酸化并减少 KRAS 突变型癌细胞的增殖。以该分子为基础的药物可能对那些对目前临床试验中的 KRAS 抑制剂没有反应的患者有效。