Barr J G, Hogg G M, Smyth E T
Ulster Med J. 1988 Apr;57(1):50-7.
A significant percentage survival, representing a large number of viable cells, can occur in a Staphylococcus aureus population exposed to concentrations of mupirocin up to 1,000 times the minimum inhibitory concentration. An elevated ratio of minimum inhibitory to minimum bactericidal concentration of mupirocin with staphylococci was recorded. Staphylococci which survive exposure to mupirocin may be less sensitive to the subsequent bactericidal action of the antibiotic. The observations may explain the re-colonisation with staphylococci seen in some studies.
在暴露于高达最低抑菌浓度1000倍的莫匹罗星浓度的金黄色葡萄球菌群体中，可能会出现显著比例的存活情况，这代表着大量有活力的细胞。记录到莫匹罗星对葡萄球菌的最低抑菌浓度与最低杀菌浓度之比升高。在暴露于莫匹罗星后存活下来的葡萄球菌可能对该抗生素随后的杀菌作用不太敏感。这些观察结果可能解释了一些研究中所见到的葡萄球菌再定植现象。
