Faculdade de Medicina da Universidade de Coimbra, Azinhaga de Santa Comba - Celas PT, 3000-548, Coimbra, Portugal.
Serviço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
J Nucl Cardiol. 2021 Aug;28(4):1461-1473. doi: 10.1007/s12350-019-01832-7. Epub 2019 Aug 6.
18-Fluorine sodium fluoride is a well-known radiotracer used for bone metastasis diagnosis. Its uptake correlation with cardiovascular (CV) risk was primarily suggested in oncological patients. Moreover, as a specific marker of microcalcification, it seems to correlate with CV disease progression and plaque instability.
Our purpose was to systematically review clinical studies that characterized the use of this marker in CV conditions. In atherosclerosis, most studies report a positive correlation with the burden of CV risk factors and vascular calcification. A higher uptake was found in culprit plaques/rupture sites in coronary and carotid arteries and it was also linked to high-risk features in histology and intravascular imaging analysis of the plaques. In aortic stenosis, this tracer displayed an increasing uptake with disease severity.
Sodium fluoride positron emission tomography is a promising non-invasive technique to identify high-risk plaques, which sets ground to a potential use of this tracer in evaluating atherosclerotic disease progression and degenerative changes in aortic valve stenosis. Nevertheless, there is a need for further prospective evidence that demonstrates this technique's value in predicting clinical events, adjusting treatment strategies, and improving patient outcomes.
18 氟氟化钠是一种众所周知的放射性示踪剂，用于骨转移诊断。其摄取与心血管（CV）风险的相关性主要在肿瘤患者中提出。此外，作为微钙化的特异性标志物，它似乎与 CV 疾病进展和斑块不稳定相关。
我们的目的是系统地综述描述这种标志物在 CV 情况下使用的临床研究。在动脉粥样硬化中，大多数研究报告与 CV 危险因素和血管钙化的负担呈正相关。在冠状动脉和颈动脉的罪犯斑块/破裂部位发现摄取增加，并且与斑块的组织学和血管内成像分析中的高危特征相关。在主动脉瓣狭窄中，这种示踪剂随着疾病严重程度的增加而摄取增加。
氟 18 正电子发射断层扫描是一种很有前途的非侵入性技术，可以识别高危斑块，为评估动脉粥样硬化疾病进展和主动脉瓣狭窄退行性变化中这种示踪剂的潜在用途奠定了基础。然而，需要进一步的前瞻性证据表明，该技术在预测临床事件、调整治疗策略和改善患者预后方面具有价值。
