Han Jong Chul, Hwang Young Hoon, Ahn Byung Heon
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Ophthalmology, Myung-Gok Eye Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2019 Aug;33(4):371-378. doi: 10.3341/kjo.2019.0027.
To investigate the outflow characteristics of silicone tubes with intraluminal stents used in membrane-tube (MT) type glaucoma shunt devices.
The silicone tubes used in MicroMT (internal diameter of 100 μm with a 7-0 nylon intraluminal stent) and Finetube MT (internal diameter of 200 μm with a 5-0 nylon intraluminal stent) were connected to a syringe-pump that delivered a continuous flow of distilled water at flow rates of 2, 5, 10, and 25 μL/min. The pressures and resistances of tubes were measured at a steady flow rate with full-length, half-length, and absence of intraluminal stents.
The mean outflow resistance of the two types of tubes ranged from 3.0 ± 1.9 to 3.8 ± 1.7 mmHg/μL/min with a full-length intraluminal stent, 1.8 ± 1.1 to 2.2 ± 1.1 mmHg/μL/min with a half-length intraluminal stent, and 0.1 ± 0.0 to 0.2 ± 0.0 mmHg/μL/min without an intraluminal stent. Theoretically, for a physiologic state with a flow rate of 2 μL/min and episcleral venous pressure of 6 mmHg, the mean pressures of tubes were expected to be 13.2 ± 3.0, 10.5 ± 2.4, and 6.4 ± 0.2 mmHg in MicroMT with full-length, half-length, and absence of intraluminal stents, respectively, and 12.5 ± 3.9, 9.6 ± 2.4, and 6.2 ± 0.2 mmHg in Finetube MT with full-length, half-length, and absence of intraluminal stents, respectively. The pressure variance also decreased with intraluminal stent retraction ( < 0.01).
The small diameter tubes of 100 and 200 μm internal diameters, with 7-0 and 5-0 nylon intraluminal stents, respectively, used in the MT-type glaucoma shunt device showed safe and effective outflow characteristics.
研究用于膜管（MT）型青光眼分流装置的带腔内支架硅胶管的流出特性。
将用于MicroMT（内径100μm，带有7-0尼龙腔内支架）和Finetube MT（内径200μm，带有5-0尼龙腔内支架）的硅胶管连接到一个注射泵上，该泵以2、5、10和25μL/分钟的流速输送蒸馏水。在腔内支架全长、半长和无腔内支架的情况下，以稳定流速测量管的压力和阻力。
两种类型的管在腔内支架全长时的平均流出阻力范围为3.0±1.9至3.8±1.7mmHg/μL/分钟，在腔内支架半长时为1.8±1.1至2.2±1.1mmHg/μL/分钟，无腔内支架时为0.1±0.0至0.2±0.0mmHg/μL/分钟。理论上，对于流速为2μL/分钟且巩膜静脉压为6mmHg的生理状态，MicroMT在腔内支架全长、半长和无腔内支架时管的平均压力预计分别为13.2±3.0、10.5±2.4和6.4±0.2mmHg，Finetube MT在腔内支架全长、半长和无腔内支架时管的平均压力预计分别为12.5±3.9、9.6±2.4和6.2±0.2mmHg。压力方差也随着腔内支架回缩而降低（<0.01）。
MT型青光眼分流装置中使用的内径分别为100μm和200μm的小直径硅胶管，分别带有7-0和5-0尼龙腔内支架，显示出安全有效的流出特性。
