Université de Nantes, CEISAM, Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation, UMR CNRS 6230, UFR des Sciences et des Techniques, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
Clermont Université, UMR 1071 Inserm/Université d'Auvergne, 63000 Clermont-Ferrand, France.
Chem Commun (Camb). 2019 Sep 4;55(68):10158-10161. doi: 10.1039/c9cc05545b. Epub 2019 Aug 7.
We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.
我们开发了一种化学方法，使甘露糖配体共价功能化纤维素纳米纤维和纤维素纸，这些甘露糖配体对来自致病性大肠杆菌菌株的 FimH 粘附素具有很强的亲和力。接枝甘露糖的纤维素能够有效地选择性结合 FimH 凝集素，并区分致病性和非致病性大肠杆菌菌株。这些改性纸张是诊断由大肠杆菌引起的感染的有价值的工具，例如膀胱炎或炎症性肠病，并且该概念可能适用于其他危及生命的病原体。
