Department of Infectious Diseases, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Clinics (Sao Paulo). 2019;74:e775. doi: 10.6061/clinics/2019/e775. Epub 2019 Aug 5.
Bilirubin is considered an important antioxidant, anti-inflammatory factor and immunomodulator. The current investigation aimed to explore the association between bilirubin and white blood cell (WBC) count in a large Chinese cohort.
A total of 61091 participants (29259 males, 31832 females) were recruited from a Chinese tertiary hospital. Data were sorted by sex, and the association between bilirubin and WBC count was analyzed after dividing bilirubin levels into quartiles.
Most parameters (including age, body mass index, systolic blood pressure, diastolic blood pressure, alanine aminotransferase, total bilirubin, blood urea nitrogen, creatinine, uric acid, triglycerides and WBC count) were significantly higher in men than in women. Bilirubin displayed significant negative relationships with most other measured variables. Linear logistic regression analysis further indicated their negative relationships. Females showed a significantly higher frequency of leucopenia than males. Significant associations of leucopenia with high bilirubin quartiles were shown in binary logistic regression models for both sexes, with a much closer association in men than in women. For instance, for men with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.600-times higher than that of men with values in quartile 1. For women with bilirubin levels in quartile 4, the adjusted likelihood of leucopenia was 1.135-times higher than that of women with values in quartile 1.
Bilirubin is negatively related to WBC count. Significant associations exist between leucopenia and high bilirubin quartiles, and these associations are more obvious in men than in women.
胆红素被认为是一种重要的抗氧化剂、抗炎因子和免疫调节剂。本研究旨在探讨大型中国队列中胆红素与白细胞（WBC）计数之间的关系。
共招募了来自中国一家三级医院的 61091 名参与者（男性 29259 名，女性 31832 名）。根据性别对数据进行排序，并将胆红素水平分为四等份，分析胆红素与 WBC 计数之间的关系。
大多数参数（包括年龄、体重指数、收缩压、舒张压、丙氨酸氨基转移酶、总胆红素、血尿素氮、肌酐、尿酸、甘油三酯和 WBC 计数）在男性中均显著高于女性。胆红素与大多数其他测量变量呈显著负相关。线性逻辑回归分析进一步表明了它们之间的负相关关系。女性白细胞减少症的发生率明显高于男性。在男女两性的二项逻辑回归模型中，白细胞减少症与高胆红素四分位的显著关联，男性的关联比女性更密切。例如，对于胆红素水平在四分位 4 的男性，白细胞减少症的调整可能性是胆红素水平在四分位 1 的男性的 1.600 倍。对于胆红素水平在四分位 4 的女性，白细胞减少症的调整可能性是胆红素水平在四分位 1 的女性的 1.135 倍。
胆红素与 WBC 计数呈负相关。白细胞减少症与高胆红素四分位之间存在显著关联，且在男性中比女性更明显。
