中国人群中代谢综合征与白细胞计数之间的正相关关系。
Positive association between the metabolic syndrome and white blood cell counts in Chinese.
作者信息
Yang Hong, Fu Yuan-Qing, Yang Bo, Zheng Ju-Sheng, Zeng Xiao-Yun, Zeng Wen, Fan Zhi-Fen, Chen Min, Wang Ling, Li Duo
机构信息
Wuhan Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Maternal and Infant Nutrition, Beingmate Research Institute, Hangzhou, China.
出版信息
Asia Pac J Clin Nutr. 2017 Jan;26(1):141-147. doi: 10.6133/apjcn.102015.13.
BACKGROUND AND OBJECTIVES
The aim was to investigate the association between peripheral circulating white blood cell count (WBC) and the metabolic syndrome among populations in central China.
METHODS AND STUDY DESIGN
In the present study, 5,278 subjects (2,412 women, 2,866 men) aged 18-75 years were recruited through a health check program in Wuhan, China. Biochemical and haematological parameters were measured by standard methods and the metabolic syndrome diagnosed as defined by the Chinese Diabetes Society criteria for Chinese.
RESULTS
Both WBC counts and prevalence of metabolic syndrome were significantly higher in men than in women (p<0.01). Participants in the highest quartile of white blood cell count had significantly higher odds ratio of metabolic syndrome (3.79, 95% CI: 2.64, 5.44), compared with subjects in the lowest quartile. The trend remained significant after adjustment for confounding factors and in further subgroup-analyses.
CONCLUSIONS
Metabolic syndrome prevalence was significantly and positively correlated with the total white blood cell count in this Chinese population.
背景与目的
旨在研究中国中部人群外周循环白细胞计数（WBC）与代谢综合征之间的关联。
方法与研究设计
在本研究中，通过中国武汉的一项健康检查项目招募了5278名年龄在18 - 75岁之间的受试者（2412名女性，2866名男性）。采用标准方法测量生化和血液学参数，并根据中国糖尿病学会制定的中国标准诊断代谢综合征。
结果
男性的白细胞计数和代谢综合征患病率均显著高于女性（p<0.01）。与白细胞计数最低四分位数的受试者相比，白细胞计数最高四分位数的参与者患代谢综合征的比值比显著更高（3.79，95%可信区间：2.64，5.44）。在调整混杂因素后以及进一步的亚组分析中，该趋势仍然显著。
结论
在该中国人群中，代谢综合征患病率与白细胞总数显著正相关。
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