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雄激素剥夺疗法男性干预的可行性:研究方案。

Feasibility of an intervention for men on androgen deprivation therapy: A research protocol.

机构信息

School of Nursing, University of Kansas Medical Center, Kansas City, Kansas.

Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas.

出版信息

Res Nurs Health. 2019 Oct;42(5):324-333. doi: 10.1002/nur.21977. Epub 2019 Aug 7.

Abstract

Androgen deprivation therapy (ADT) is a treatment used across the prostate cancer disease spectrum and works by suppressing testicular androgen production to castrate levels. Although ADT can provide survival benefits, it is also associated with increased risk for cardiovascular disease, metabolic syndrome, increased visceral fat mass, dyslipidemia, decreased arterial compliance, and diminished health-related quality of life. The Staying Strong And Healthy protocol is a telephone-delivered intervention led by a nurse coordinator to minimize the increased cardiovascular and metabolic risks associated with ADT. This study will evaluate the feasibility of the protocol and provides the foundation for future behavioral interventions across diverse populations of men on ADT.

摘要

雄激素剥夺疗法(ADT)是一种用于前列腺癌疾病谱的治疗方法,通过抑制睾丸雄激素产生来达到去势水平。虽然 ADT 可以提供生存益处,但它也与心血管疾病、代谢综合征、内脏脂肪增加、血脂异常、动脉顺应性降低和健康相关生活质量下降的风险增加相关。“保持强壮和健康”方案是一种由护士协调员主导的电话干预措施,旨在最大限度地降低与 ADT 相关的心血管和代谢风险增加。这项研究将评估该方案的可行性,并为未来在接受 ADT 的不同人群中开展行为干预提供基础。

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