镍催化酰氯的脱羰氰化反应。
Nickel-Catalyzed Decarbonylative Cyanation of Acyl Chlorides.
机构信息
Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
Department of Chemistry, Biology, and Environmental Science, Faculty of Science, Nara Women's University, Kitauoyanshi-machi, Nara 630-8506, Japan.
出版信息
Org Lett. 2019 Sep 6;21(17):6779-6784. doi: 10.1021/acs.orglett.9b02398. Epub 2019 Aug 7.
Ni-catalyzed decarbonylative cyanation of acyl chlorides with trimethylsilyl cyanide has been achieved. This transformation is applicable to the synthesis of an array of nitrile compounds bearing a wide range of functional groups under neutral conditions. The step-by-step experimental studies revealed that the reaction sequences of the present catalytic reaction are oxidative addition, transmetalation, decarbonylation, and reductive elimination.
镍催化酰氯与三甲基硅氰的脱羰氰化反应已经实现。这种转化适用于在中性条件下合成带有广泛官能团的一系列腈类化合物。逐步的实验研究表明，本催化反应的反应序列为氧化加成、转金属、脱羰和还原消除。
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