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心房机电持续时间延长与勃起功能障碍患者相关。

Atrial electromechanical duration prolongs in patients with erectile dysfunction.

机构信息

Department of Urology, University of Health Sciences, Adana City Teaching and Research Hospital, Adana, Turkey.

Department of Family Medicine, Public Health Institution of Çukurova, Adana, Turkey.

出版信息

Aging Male. 2020 Jun;23(2):154-160. doi: 10.1080/13685538.2019.1650336. Epub 2019 Aug 7.

Abstract

It is well known that erectile dysfunction (ED) is associated with increased risk of atrial fibrillation (AF) development. On the other hand, prolongation of the duration of atrial electromechanical delay (AEMD) is known to be a precursor for AF development. We aimed to evaluate AEMD in patients with ED patients without documented AF. Total of 68 outpatients with previously documented vascular ED and 44 participants without ED were enrolled to the current study. Sixty-eight patients with ED called as ED group and 44 participants without ED served as control group. We performed International Index of Erectile Function (IIEF-5) questionnaire for all participants to determine the disease severity of ED groups and to diagnose ED in control groups. Patients with a IIEF-5 score ≥22 were defined as having normal erectile functions. Both intra- and inter-AEMD were measured with tissue Doppler imaging. P-wave dispersion (PWD) was measured on a 12-lead electrocardiogram. Basal characteristics were similar between the two groups. PWD, inter- and right intra-AEMD were significantly prolonged in patients with ED, compared to the control group ( .02, < .001 and < .001, respectively). In the correlation analysis, IIEF-5 score was significantly negative correlated with systolic blood pressure, right intra- and inter-AEMD ( -0.37,  .02; = -0.27,  .02; -0.39,  .001, respectively). According to current study results, AEMD is significantly correlated with ED severity and may be useful to stratify ED patients to the high-risk group for future development of AF as a cheap and easy method.

摘要

众所周知,勃起功能障碍(ED)与心房颤动(AF)发展的风险增加有关。另一方面,已知心房机电延迟(AEMD)时间延长是 AF 发展的前兆。我们旨在评估无记录 AF 的 ED 患者的 AEMD。共有 68 名先前有记录的血管性 ED 门诊患者和 44 名无 ED 的参与者被纳入本研究。68 名 ED 患者称为 ED 组,44 名无 ED 的参与者作为对照组。我们对所有参与者进行了国际勃起功能指数(IIEF-5)问卷,以确定 ED 组疾病的严重程度,并在对照组中诊断 ED。IIEF-5 评分≥22 的患者被定义为勃起功能正常。所有参与者均进行组织多普勒成像测量 AEMD 的室内和室内间隔。在 12 导联心电图上测量 P 波离散度(PWD)。两组的基本特征相似。与对照组相比,ED 患者的 PWD、室内和右室内 AEMD 明显延长(分别为<0.02、<0.001 和<0.001)。在相关性分析中,IIEF-5 评分与收缩压、右室内和室内间隔 AEMD 呈显著负相关(分别为-0.37、0.02;-0.27、0.02;-0.39、0.001)。根据当前的研究结果,AEMD 与 ED 严重程度显著相关,可能是一种廉价且易于使用的方法,可将 ED 患者分层为未来发生 AF 的高危人群。

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