Chowdhry Shilpa Mukunda, Chowdhry Varun Kumar
Department of Geriatrics and Palliative Medicine, State University of New York at Buffalo.
Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Curr Opin Support Palliat Care. 2019 Dec;13(4):292-297. doi: 10.1097/SPC.0000000000000450.
Cancer cachexia is a metabolic disturbance resulting in a loss of skeletal muscle mass that is generally not reversed through traditional nutritional interventions. We review on both the impact of nutritional status on cancer treatment side effects, as well as cancer- specific outcomes.
Cancer-specific cachexia and sarcopenia are associated with increased treatment-associated toxicity, and overall worse cancer-specific outcomes across all cancer types in surgical, chemotherapeutic, and radiotherapeutic populations. Despite the fact that cancer cachexia is generally thought to be irreversible, there is some evidence that nutritional intervention can be helpful.
Nutritional status is an important factor to consider in determining cancer therapy. Patients with poor nutritional status should be identified prior to the initiation of therapy and be monitored judiciously.
癌症恶病质是一种代谢紊乱，导致骨骼肌质量丧失，通常无法通过传统营养干预措施逆转。我们将综述营养状况对癌症治疗副作用以及癌症特异性结局的影响。
癌症特异性恶病质和肌肉减少症与治疗相关毒性增加有关，并且在手术、化疗和放疗人群中，所有癌症类型的癌症特异性结局总体上更差。尽管一般认为癌症恶病质是不可逆的，但有一些证据表明营养干预可能会有所帮助。
营养状况是确定癌症治疗方案时需要考虑的重要因素。营养状况不佳的患者应在治疗开始前确定，并进行审慎监测。
