KRAB ZNF 探索者——一个在线工具，用于探索癌症基因组图谱中 KRAB-ZNF 因子的转录组特征。
KRAB ZNF explorer-the online tool for the exploration of the transcriptomic profiles of KRAB-ZNF factors in The Cancer Genome Atlas.
机构信息
Faculty of Mathematics, Informatics, and Mechanics, University of Warsaw, 02-097 Warsaw, Poland.
Faculty of Mathematics and Information Science, Warsaw University of Technology, 00-662 Warsaw, Poland.
出版信息
Bioinformatics. 2020 Feb 1;36(3):980-981. doi: 10.1093/bioinformatics/btz624.
SUMMARY
Krüppel-associated box domain zinc finger protein (KRAB ZNF) explorer is a web-based tool for comprehensive characterization of the mRNA expression status of KRAB-ZNF transcription factors in the data from The Cancer Genome Atlas study. Key functionalities cover a comparative analysis of KRAB-ZNF expression between normal and cancer tissues, an association of KRAB-ZNF expression with various pathological features, including survival analysis, association with global DNA methylation status, analyses of KRAB-ZNF isoform expressions and analysis of KRAB-ZNF levels in normal tissues.
AVAILABILITY AND IMPLEMENTATION
KRAB ZNF explorer is available at http://mi2.mini.pw.edu.pl: 8080/KRAB_ZNF/. The source code for shiny application is available at: https://github.com/MI2DataLab/KRAB_ZNF/tree/master/app and the source code for analyses and precalculations are available at: https://github.com/MI2DataLab/KRAB_ZNF/tree/master/work.
摘要
Krüppel 相关盒域锌指蛋白（KRAB ZNF）探索者是一个基于网络的工具，用于全面描述癌症基因组图谱研究数据中 KRAB-ZNF 转录因子的 mRNA 表达状态。主要功能包括正常组织和肿瘤组织之间 KRAB-ZNF 表达的比较分析、KRAB-ZNF 表达与各种病理特征的关联，包括生存分析、与全球 DNA 甲基化状态的关联、KRAB-ZNF 异构体表达的分析以及正常组织中 KRAB-ZNF 水平的分析。
可用性和实现
KRAB ZNF 探索者可在 http://mi2.mini.pw.edu.pl:8080/KRAB_ZNF/ 访问。shiny 应用程序的源代码可在：https://github.com/MI2DataLab/KRAB_ZNF/tree/master/app 获得，分析和预计算的源代码可在：https://github.com/MI2DataLab/KRAB_ZNF/tree/master/work 获得。
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