阿尔茨海默病中皮质神经元的大量体树突状发芽。
Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease.
作者信息
Ihara Y
机构信息
Tokyo Metropolitan Institute of Gerontology, Japan.
出版信息
Brain Res. 1988 Aug 30;459(1):138-44. doi: 10.1016/0006-8993(88)90293-4.
PMID:3139259
Abstract
In addition to neurofibrillary tangles and senile plaques, antibodies to human tau revealed extensive tau-immunoreactive meshworks in layers III and V of the neocortex affected with Alzheimer's disease. The meshworks consisted of innumerable abnormally curly fibers, which were coming from somata and dendrites of pyramidal cells. Their morphological appearance suggests that those curly fibers represent somatodendritic sprouting.
摘要
除了神经原纤维缠结和老年斑外，针对人tau蛋白的抗体还在受阿尔茨海默病影响的新皮质III层和V层中发现了广泛的tau免疫反应性网络。这些网络由无数异常卷曲的纤维组成，这些纤维来自锥体细胞的胞体和树突。它们的形态外观表明，那些卷曲的纤维代表体细胞树突发芽。
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