Kruithof E K
Department of Medicine, University Hospital, Lausanne, Switzerland.
Enzyme. 1988;40(2-3):113-21. doi: 10.1159/000469153.
Plasminogen activator inhibitors (PAIs) are important modulators of the activity of plasminogen activators (PAs). Several inhibitors, all belonging to the serpin family of proteins, have been implicated in PA inhibition. In order of reaction rate constants these are PAI-1, PAI-2, protease nexin and PAI-3. This review gives an overview of the physicochemical characteristics of these inhibitors as well as a comparison of their primary structure with each other and with other members of the serpin family of proteins.
纤溶酶原激活物抑制剂（PAIs）是纤溶酶原激活物（PAs）活性的重要调节剂。几种抑制剂都属于丝氨酸蛋白酶抑制剂（serpin）家族蛋白，与PA抑制有关。按照反应速率常数排序，它们依次是PAI-1、PAI-2、蛋白酶连接蛋白和PAI-3。本文综述了这些抑制剂的物理化学特性，并比较了它们彼此之间以及与丝氨酸蛋白酶抑制剂家族其他成员的一级结构。
