UCL Medical School, London, UK; North End Medical Centre, London, UK.
College of Pharmacy, University of Duhok, Iraq.
Photodiagnosis Photodyn Ther. 2019 Dec;28:172-176. doi: 10.1016/j.pdpdt.2019.08.004. Epub 2019 Aug 5.
Photodynamic therapy (PDT) is a method of treating various pathologies. In this retrospective study with prospective intent, a total of 22 patients with T1/T2 N0 cutaneous squamous cell carcinoma (SCC) were treated with intravenous mTHPC (meta-tetrahydroxyphenylchlorin) and surface illumination PDT. Comparisons with the clinical features, rate of recurrence and overall outcome were made.
Surface illumination PDT was offered under local anaesthesia. 0.05 mg/kg mTHPC was administered intravenously into the midcubital vein 48 h prior to tissue illumination. A single-channel 652 nm diode laser was used for illumination and light was delivered at 20 J/cm per site. Lesion response evaluation was carried out according to Response Evaluation Criteria In Solid Tumors (RECIST).
Clinical assessment revealed that 16 patients had lesions of <2 cm in size (T1), while the rest were T2. No nodal involvement was identified in any of the patients. None of the patients had a locally recurrent lesion. During the 3-year follow-up, 20/22 patients had complete response (CR) and this was after one round of treatment. Two patients suffered from recurrent disease within 3 years of the follow-up, and they underwent surgical resection.
PDT achieved high efficacy in the treatment of T1N0 cutaneous squamous cell carcinoma with greatly reduced morbidity and disfigurement. The technique is simple, can commonly be carried out in outpatient clinics, and is highly acceptable to patients.
光动力疗法（PDT）是一种治疗多种疾病的方法。在这项前瞻性回顾性研究中，共 22 例 T1/T2N0 皮肤鳞状细胞癌（SCC）患者接受了静脉注射 mTHPC（间四羟苯基氯）和表面光照 PDT 治疗。对其临床特征、复发率和总体结局进行了比较。
在局部麻醉下进行表面光照 PDT。在组织光照前 48 小时，静脉内给予 0.05mg/kg mTHPC。使用单通道 652nm 二极管激光进行光照，每个部位的光剂量为 20J/cm。根据实体瘤反应评价标准（RECIST）进行病变反应评估。
临床评估显示，16 例患者的病变大小<2cm（T1），其余为 T2。所有患者均无淋巴结受累。无一例患者有局部复发病灶。在 3 年的随访期间，22 例患者中有 20 例达到完全缓解（CR），这是在一轮治疗后。两名患者在随访 3 年内患有复发性疾病，他们接受了手术切除。
PDT 治疗 T1N0 皮肤鳞状细胞癌的疗效高，发病率和毁容率低。该技术简单，通常可在门诊进行，患者高度接受。
