Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Environ Pollut. 2019 Nov;254(Pt A):112971. doi: 10.1016/j.envpol.2019.112971. Epub 2019 Jul 30.
The effects of exposure to some environmental chemicals on blood pressure have been determined, but the association between non-occupational exposure to perfluoroalkyl substances (PFASs) and blood pressure in adolescents remains unknown. The association between blood pressure and PFAS concentrations was studied by analysing data from 2251 participants filtered from the population enrolled in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2012. After adjusting for age, sex, race, BMI, cotinine level, dietary intake of calcium, caloric intake, sodium consumption, potassium consumption and sampling year, we estimated the coefficients (betas) and 95% confidence intervals (CIs) for the relationship between PFAS concentrations and blood pressure with multiple linear regression models. Potential non-linear relationships were assessed with restricted cubic spline models. Blood levels of perfluorooctane sulfonic acid (PFOS) had a strong positive association with diastolic blood pressure (DBP) in adolescents in the linear model, while the result was not significant in the non-linear model. No significant association was observed between the concentration of any other PFASs and blood pressure. According to the fully adjusted linear regression model (P = 0.041), the mean DBP values in boys in the higher PFOS quintile were 2.70% greater than the mean DBP values of boys in the lowest PFOS quintile. Furthermore, serum PFOS concentrations predominantly affected blood pressure in male adolescents compared with female adolescents. These results provide epidemiological evidence of PFOS-related increases in DBP. Further research is needed to address related issues.
已经确定了某些环境化学物质暴露对血压的影响，但非职业性接触全氟烷基物质 (PFAS) 与青少年血压之间的关联尚不清楚。通过分析 2003 年至 2012 年全国健康和营养检查调查 (NHANES) 中筛选出的 2251 名参与者的数据，研究了血压与 PFAS 浓度之间的关联。在校正年龄、性别、种族、BMI、可替宁水平、钙的饮食摄入量、热量摄入量、钠摄入量、钾摄入量和采样年份后，我们使用多元线性回归模型估计了 PFAS 浓度与血压之间的关系的系数（β）和 95%置信区间 (CI)。使用限制立方样条模型评估了潜在的非线性关系。全氟辛烷磺酸 (PFOS) 的血水平与青少年的舒张压 (DBP) 在线性模型中呈强正相关，而在非线性模型中结果不显著。任何其他 PFAS 浓度与血压之间均无显著关联。根据完全调整的线性回归模型（P=0.041），较高 PFOS 五分位组男孩的平均 DBP 值比最低 PFOS 五分位组男孩的平均 DBP 值高 2.70%。此外，血清 PFOS 浓度主要影响男性青少年的血压，而不是女性青少年的血压。这些结果提供了与 PFOS 相关的 DBP 升高的流行病学证据。需要进一步研究来解决相关问题。
