Centers for Water and Health, Key Laboratory of Public Health Safety, Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the Peoples' Republic of China, Fudan University, Shanghai 200032, China; Department of Nutrition and Food Hygiene and Chemistry, School of Public Health, Fudan University, Shanghai 200032, China; Pudong New Area for Disease Control and Prevention, Fudan University Pudong Institute of Preventive Medicine, Shanghai 200136, China.
Centers for Water and Health, Key Laboratory of Public Health Safety, Ministry of Education, Key Lab of Health Technology Assessment, National Health Commission of the Peoples' Republic of China, Fudan University, Shanghai 200032, China; Department of Nutrition and Food Hygiene and Chemistry, School of Public Health, Fudan University, Shanghai 200032, China.
Environ Pollut. 2019 Nov;254(Pt A):112921. doi: 10.1016/j.envpol.2019.07.089. Epub 2019 Jul 23.
The associations between bisphenol analogues (BPs) exposure and oxidative damage was explored in this 3-year longitudinal study of 275 school children in East China. Nine BPs in first morning urine samples were measured to assess BPs exposure, and 8-hydroxydeoxyguanosine (8-OHdG) and 8-oxo-7,8-dihydroguanosine (8-OHG) were measured as biomarkers of oxidative DNA and RNA damage. Linear mixed model (LMM) was used for repeated measures analysis. School children were mainly exposed to BPA, BPS, BPF, and BPAF (detection frequencies: 97.9%, 42.2%, 13.3%, and 12.8%) with median concentrations of 1.55, 0.355, 0.236 and 0.238 μg g, respectively. An interquartile range (IQR) increase in urinary BPA was significantly associated with 12.9% (95% CI: 6.1%, 19.6%) increase in 8-OHdG and 19.4% (95% CI: 11.7%, 27.1%) increase in 8-OHG, and for total of BPs (the sum of BPA, BPS, BPF, and BPAF), they were 17.4% (95% CI: 8.9%, 26.0%) for 8-OHdG and 25.9% (95% CI: 16.1%, 35.7%) for 8-OHG, respectively. BPS was positively associated with 8-OHG, but not with 8-OHdG. The study found positive associations of urinary levels of BPA and total BPs with 8-OHdG and 8-OHG and indicated that BPs exposure might cause oxidative RNA damage.
本研究对华东地区 275 名学童进行了为期 3 年的纵向研究，旨在探讨双酚类似物 (BPs) 暴露与氧化损伤之间的关系。通过检测晨尿样本中的 9 种 BPs，评估 BPs 暴露情况，并检测 8-羟基脱氧鸟苷 (8-OHdG) 和 8-氧代-7,8-二氢鸟苷 (8-OHG) 作为氧化 DNA 和 RNA 损伤的生物标志物。采用线性混合模型 (LMM) 进行重复测量分析。研究发现，学童主要暴露于 BPA、BPS、BPF 和 BPAF（检出率：97.9%、42.2%、13.3%和 12.8%），中位数浓度分别为 1.55、0.355、0.236 和 0.238μg/g。尿中 BPA 每增加一个四分位间距 (IQR)，8-OHdG 增加 12.9%（95%CI：6.1%，19.6%），8-OHG 增加 19.4%（95%CI：11.7%，27.1%）；对于 BPs 总量（BPA、BPS、BPF 和 BPAF 的总和），8-OHdG 增加 17.4%（95%CI：8.9%，26.0%），8-OHG 增加 25.9%（95%CI：16.1%，35.7%）。BPS 与 8-OHG 呈正相关，但与 8-OHdG 无关。本研究发现，尿中 BPA 和 BPs 总量与 8-OHdG 和 8-OHG 呈正相关，表明 BPs 暴露可能导致 RNA 氧化损伤。
