内皮素刺激血管平滑肌细胞中c-fos和c-myc的表达以及增殖。
Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells.
作者信息
Komuro I, Kurihara H, Sugiyama T, Yoshizumi M, Takaku F, Yazaki Y
机构信息
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
出版信息
FEBS Lett. 1988 Oct 10;238(2):249-52. doi: 10.1016/0014-5793(88)80489-7.
Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium-channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c-fos and c-myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose-dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.
最近，一种强效血管收缩肽，内皮素（EDT），从血管内皮细胞中分离出来。我们研究了它对大鼠血管平滑肌细胞（VSMCs）的作用。EDT引起细胞内钙升高，这依赖于细胞外钙，并被钙通道拮抗剂竞争性抑制。EDT导致c-fos和c-myc mRNA水平快速短暂升高，并以剂量依赖方式刺激VSMCs的DNA合成。EDT对VSMCs增殖的这种作用可能与动脉粥样硬化的发展有关。
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