Zang Xiao-Ping, Lerner Megan R, Bahr Steven J, Brackett Daniel J, Pento J Thomas
Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center.
Department of Surgery, University of Oklahoma Health Sciences Center.
Cancer Genomics Proteomics. 2006 Nov-Dec;3(6):369-372. Epub 2006 Nov 1.
Keratinocyte growth factor (KGF) has been observed to produce a rapid increase in the motility of breast cancer cells. KGF/KGFR (KGF receptor) signaling has also been demonstrated in the progression of many types of human cancer. The objective of the present study was to compare KGFR expression in various types of cancer.
A cancer profiling array containing cDNA from 154 tumor and paired normal samples representing 19 types of human cancer was employed.
The results of the present study indicate that KGFR expression is enhanced in many types of human carcinomas at an early stage of cancer development, suggesting that KGFR overexpression may be an early signal in the progression of these cancers. However, the stage of cancer progression and relative level of expression varied considerably among the various types of cancer.
These findings suggest that tumor KGFR levels may serve as a prognostic biomarker for cancer staging and/or treatment.
已观察到角质形成细胞生长因子（KGF）可使乳腺癌细胞的运动能力迅速增强。KGF/KGFR（KGF受体）信号传导在多种人类癌症的进展中也得到了证实。本研究的目的是比较KGFR在不同类型癌症中的表达情况。
使用了一种癌症分析阵列，其包含来自代表19种人类癌症的154个肿瘤及配对正常样本的cDNA。
本研究结果表明，在癌症发展的早期阶段，多种类型的人类癌组织中KGFR表达增强，这表明KGFR过表达可能是这些癌症进展的早期信号。然而，癌症进展阶段和相对表达水平在不同类型癌症之间差异很大。
这些发现表明，肿瘤KGFR水平可能作为癌症分期和/或治疗的预后生物标志物。
