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上矢状窦硬脑膜动静脉瘘的大分割立体定向放射外科治疗:病例报告及文献复习

Hypofractionated stereotactic radiosurgery for dural arteriovenous fistula in the superior sagittal sinus: case report and review of the literature.

作者信息

Sung Kyoung Su, Choi Jae-Hyung, Song Young Jin, Kim Ki-Uk

机构信息

Department of Neurosurgery, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Republic of Korea.

Novalis Radiosurgery Center, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Republic of Korea.

出版信息

Br J Neurosurg. 2023 Aug;37(4):781-785. doi: 10.1080/02688697.2019.1648753. Epub 2019 Aug 9.

DOI:10.1080/02688697.2019.1648753
PMID:31397171
Abstract

Stereotactic radiosurgery (SRS) for dural arteriovenous fistula (dAVF) in the superior sagittal sinus (SSS) is not an established treatment because of relatively poor efficacy and a latency period for treatment effects. Hypofractionated SRS for these lesions has not yet been reported. A 65-year-old man presented with intermittent paraparesis. Brain magnetic resonance imaging (MRI) revealed acute infarction in the premotor and motor cortex of both frontal convexities. Cerebral angiography demonstrated extensive dAVF in the middle and posterior third SSS, associated with an occlusion in the middle third. Transfemoral arterial Onyx embolization was performed through the right middle meningeal arteries, and cerebral venous reflux (CVR) disappeared from the middle third of the SSS. However, the remnant dAVF in the posterior third of the SSS and CVR in the posterior parietal and occipital lobes remained. Novalis SRS was performed on remnant the dAVF with 35 Gy in 5 fractions. Seven months after Novalis SRS, symptoms improved and cortical engorged vessel gradually disappeared on brain MRI. The patient recovered completely at 22 months post-radiosurgery. SRS for dAVF in the SSS could provide an alternative treatment option. Hypofractionated SRS showed a good result in our case.

摘要

由于疗效相对较差且存在治疗效果潜伏期,立体定向放射外科治疗(SRS)用于上矢状窦(SSS)硬脑膜动静脉瘘(dAVF)并非一种成熟的治疗方法。针对这些病变的低分割SRS尚未见报道。一名65岁男性出现间歇性双下肢轻瘫。脑磁共振成像(MRI)显示双侧额凸面运动前区和运动皮质急性梗死。脑血管造影显示SSS中后段广泛存在dAVF,并伴有中段闭塞。通过右侧脑膜中动脉进行经股动脉Onyx栓塞,SSS中段的脑静脉回流(CVR)消失。然而,SSS后段的残余dAVF以及顶叶后部和枕叶的CVR仍然存在。对残余的dAVF采用Novalis SRS进行治疗,分5次给予35 Gy。Novalis SRS治疗7个月后,症状改善,脑MRI显示皮质充血血管逐渐消失。患者在放射外科治疗后22个月完全康复。SSS中dAVF的SRS可提供一种替代治疗选择。在我们的病例中,低分割SRS显示出良好的效果。

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