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出血性巨大脑毛细血管扩张症导致死亡:病例报告及文献综述

Hemorrhagic giant cerebral capillary telangiectasia resulting in death: Case report and literature review.

作者信息

Kesserwan Mohamad A, Shakil Husain, Fong Crystal, Provias John P

出版信息

Clin Neuropathol. 2019 Nov/Dec;38(6):276-284. doi: 10.5414/NP301181.

Abstract

We report a rare case of death caused by hemorrhage of a giant cerebral central nervous system capillary telangiectasia (CCT). A 49-year-old female presented comatose after suffering a traumatic head injury due to an unwitnessed fall. Computed tomography of the head revealed an acute 8.1 × 5.2 cm right intraparenchymal hematoma. Postmortem pathology found thin-walled dilated capillaries consistent with a giant cerebral CCT. The radiological complexity and rarity of giant CCTs result in these malformations often going undiagnosed. We review other cases of giant intracranial CCTs reported in the English literature and confirm that this is the first case of a hemorrhagic giant cerebral CCT causing death. This report emphasizes the existence and complications of giant CCTs and stresses the importance of their investigation to ensure patients receive optimal treatment and follow-up.

摘要

我们报告了一例罕见的因巨大脑中枢神经系统毛细血管扩张症(CCT)出血导致死亡的病例。一名49岁女性在因无人目睹的摔倒而头部受伤后昏迷。头部计算机断层扫描显示右侧脑实质内有一个8.1×5.2厘米的急性血肿。尸检病理发现薄壁扩张的毛细血管,符合巨大脑CCT。巨大CCT的放射学复杂性和罕见性导致这些畸形常常未被诊断出来。我们回顾了英文文献中报道的其他巨大颅内CCT病例,并确认这是第一例因出血性巨大脑CCT导致死亡的病例。本报告强调了巨大CCT的存在及其并发症,并强调了对其进行检查以确保患者得到最佳治疗和随访的重要性。

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