Department of Nephrology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, China.
Department of Urology, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, China.
Clin Chim Acta. 2019 Nov;498:1-5. doi: 10.1016/j.cca.2019.08.001. Epub 2019 Aug 6.
Shrunken pore syndrome (SPS) is a condition in which the estimated glomerular filtration rate (eGFR) based on serum/plasma cystatin C concentration is significantly lower than the eGFR based on creatinine. According to the literatures, the diagnosis of SPS could be defined when the eGFR is <70% of eGFR. Although the incidence of SPS varies in different patient populations and healthy seniors, it has been demonstrated that patients with SPS have poor prognosis. The present review has summarized its diagnosis, epidemiology, prognosis and possible pathophysiology basis. Moreover, we discuss the prevention and treatment of SPS in clinical practice as future challenges.
缩小毛孔综合征（SPS）是一种基于血清/血浆胱抑素 C 浓度估算的肾小球滤过率（eGFR）明显低于基于肌酐的 eGFR 的情况。根据文献，当 eGFR 低于 eGFR 的 70%时，可以诊断为 SPS。尽管 SPS 在不同的患者人群和健康老年人中的发生率不同，但已经证明 SPS 患者的预后较差。本综述总结了其诊断、流行病学、预后和可能的病理生理学基础。此外，我们还讨论了临床实践中 SPS 的预防和治疗作为未来的挑战。
