Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Mol Cell. 2019 Aug 8;75(3):415-416. doi: 10.1016/j.molcel.2019.07.020.
In Mutant INS-gene-induced Diabetes of Youth (MIDY) syndrome, mutant proinsulin aggregates interfere with the folding of wild-type proinsulin in the endoplasmic reticulum, ultimately decreasing insulin secretion. In this issue of Molecular Cell, Cunningham et al. (2019) identify two mechanisms by which prohormone aggregation is prevented and cleared.
在青少年发病的成人型糖尿病（MIDY）综合征中，突变的胰岛素原聚集物会干扰内质网中野生型胰岛素原的折叠，最终导致胰岛素分泌减少。在本期《分子细胞》中，坎宁安等人（2019）确定了两种防止和清除前激素聚集的机制。
