Division of Psychiatry, University College London, 149 Tottenham Court Road, London W1T 7BN, UK.
Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, 16 De Crespigny Park, London, SE5 8AB, UK; Department of Exercise Sciences, University of Toronto, 27 King's College Circle, Toronto, Ontario, ON M5S, Canada.
J Affect Disord. 2019 Oct 1;257:748-757. doi: 10.1016/j.jad.2019.07.088. Epub 2019 Jul 30.
Physical activity is associated with a lower incidence of common mental health disorder, but less is known about the impact of cardiorespiratory fitness (CRF).
In this review, we systematically evaluated the relationship between CRF and the incidence of common mental health disorders in prospective cohort studies. We systematically searched six major electronic databases from inception to 23rd of May 2019. We assessed study quality using the Newcastle-Ottawa scale.
We were able to pool the hazard ratios (HRs) and 95% confidence intervals (CIs) of four studies including at least 27,733,154 person-years of data. We found that low CRF (HR = 1.47, [95% CI 1.23 - 1.76] p < 0.001 I = 85.1) and medium CRF (HR = 1.23, [95% CI 1.09 - 1.38] p < 0.001 I = 87.20) CRF are associated with a 47% and 23% greater risk of a common mental health disorders respectively, compared with high CRF. We found evidence to suggest a dose-response relationship between CRF and the risk of common mental health disorders.
We were only able to identify a small number of eligible studies from our search and heterogeneity was substantial in the subsequent meta-analysis.
Our findings indicate that there is a longitudinal association between CRF levels and the risk of a common mental health disorder. CRF levels could be useful for identifying and preventing common mental health disorders at a population-level.
身体活动与常见精神健康障碍的发病率较低有关，但对于心肺适能（CRF）的影响知之甚少。
在本综述中，我们系统地评估了前瞻性队列研究中 CRF 与常见精神健康障碍发生率之间的关系。我们从成立到 2019 年 5 月 23 日系统地搜索了六个主要的电子数据库。我们使用纽卡斯尔-渥太华量表评估研究质量。
我们能够汇总四项研究的危害比（HR）和 95%置信区间（CI），这些研究至少包含 27733154 人年的数据。我们发现低 CRF（HR=1.47，[95%CI 1.23-1.76]p<0.001 I=85.1）和中等 CRF（HR=1.23，[95%CI 1.09-1.38]p<0.001 I=87.20）与高 CRF 相比，分别与常见精神健康障碍的风险增加 47%和 23%相关。我们有证据表明 CRF 与常见精神健康障碍风险之间存在剂量反应关系。
我们只能从搜索中确定少数符合条件的研究，随后的荟萃分析中存在很大的异质性。
我们的研究结果表明，CRF 水平与常见精神健康障碍风险之间存在纵向关联。CRF 水平可用于在人群水平上识别和预防常见精神健康障碍。
