巴尔通体心内膜炎的诊断与治疗

Diagnosis and treatment of Bartonella endocarditis.

作者信息

Kuncová K, Žemličková H, Jäger J, Ryšková L, Plíšková L, Bolehovská R, Pojar M

出版信息

Epidemiol Mikrobiol Imunol. 2019 Spring;68(2):104-108.

Abstract

The Bartonella genus comprises more than 20 species of Gram-negative rods which are difficult to culture. These are facultative intracellular bacteria. Humans are reservoir hosts for B. quintana and B. bacilliformis or accidental hosts for other species. Bartonella is a cause of zoonosis. Bartonella infection can be completely asymptomatic or can be linked to various conditions. Our experience with Bartonella endocarditis from 2012-2017 is presented. The most effective diagnostic method for Bartonella endocarditis is PCR detection of DNA of the pathogen from excised valve tissue. The European Society of Cardiology (ESC) in the guidelines from 2015 recommends the combination doxycycline gentamycin for the treatment of Bartonella endocarditis.

摘要

巴尔通体属包含20多种革兰氏阴性杆菌，这些细菌难以培养。它们是兼性胞内菌。人类是五日热巴尔通体和杆菌状巴尔通体的储存宿主，或是其他种类巴尔通体的偶然宿主。巴尔通体是一种人畜共患病的病原体。巴尔通体感染可能完全无症状，也可能与多种病症有关。本文介绍了我们在2012年至2017年期间治疗巴尔通体心内膜炎的经验。诊断巴尔通体心内膜炎最有效的方法是通过PCR检测切除瓣膜组织中病原体的DNA。欧洲心脏病学会（ESC）在2015年的指南中推荐使用强力霉素联合庆大霉素治疗巴尔通体心内膜炎。