使用下一代测序技术在一名血培养阴性的心内膜炎患者中鉴定出一种新出现的病原体——文森巴尔通体。
Identification of an Emergent Pathogen, Bartonella vinsonii, Using Next-Generation Sequencing in a Patient With Culture-Negative Endocarditis.
作者信息
Downey Rachel D, Russo Susan M, Hauger Sarmistha B, Murphey Donald K, Marx Grace, Huynh Thanhthao, Denison Amy M, Quirt Rachel, Bailey Ann, Fernandez Marisol
机构信息
Dell Children's Medical Center, Austin, Texas, USA.
Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
出版信息
J Pediatric Infect Dis Soc. 2021 Mar 26;10(2):213-216. doi: 10.1093/jpids/piaa014.
Abstract
Diagnosis and treatment of culture negative endocarditis remains a challenge. This report describes a rare cause of endocarditis in humans, Bartonella vinsonii, identified through next generation sequencing of plasma microbial cell-free DNA with confirmation of cardiac valve tissue infection through immunohistochemical staining and polymerase chain reaction.
摘要
血培养阴性的心内膜炎的诊断和治疗仍然是一项挑战。本报告描述了一种人类心内膜炎的罕见病因——文森巴尔通体，它是通过对血浆微生物游离DNA进行二代测序鉴定出来的，并通过免疫组化染色和聚合酶链反应证实了心脏瓣膜组织感染。
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