重组Elabela-Fc融合蛋白可延长血浆半衰期，并减轻大鼠心肌梗死后的心功能障碍。 - Suppr

Suppr

超能文献

Recombinant Elabela-Fc fusion protein has extended plasma half-life and mitigates post-infarct heart dysfunction in rats.

作者信息

Wang Yajing

机构信息

Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, United States of America.

出版信息

Int J Cardiol. 2020 Feb 1;300:217-218. doi: 10.1016/j.ijcard.2019.06.043. Epub 2019 Jun 20.

DOI:10.1016/j.ijcard.2019.06.043

PMID:31399296

Abstract

摘要

相似文献

Recombinant Elabela-Fc fusion protein has extended plasma half-life and mitigates post-infarct heart dysfunction in rats.重组Elabela-Fc融合蛋白可延长血浆半衰期，并减轻大鼠心肌梗死后的心功能障碍。

Int J Cardiol. 2020 Feb 1;300:217-218. doi: 10.1016/j.ijcard.2019.06.043. Epub 2019 Jun 20.

Recombinant Fc-Elabela fusion protein has extended plasma half-life andmitigates post-infarct heart dysfunction in rats.重组 Fc-Elabela 融合蛋白具有延长的血浆半衰期，并减轻大鼠心肌梗死后心功能障碍。

Int J Cardiol. 2019 Oct 1;292:180-187. doi: 10.1016/j.ijcard.2019.04.089. Epub 2019 Apr 30.

Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein.人粒细胞集落刺激因子/免疫球蛋白融合蛋白的循环半衰期延长及造血特性增强

Exp Hematol. 2004 May;32(5):441-9. doi: 10.1016/j.exphem.2004.01.012.

The N-terminal alanine-extended GLP-1/IgG-Fc fusion protein confers resistance to DPP-IV and reduces serum glucose level in db/db mice.N端丙氨酸延伸的GLP-1/IgG-Fc融合蛋白赋予对二肽基肽酶-IV的抗性并降低db/db小鼠的血糖水平。

Regul Pept. 2011 Oct 10;170(1-3):1-3. doi: 10.1016/j.regpep.2011.05.002. Epub 2011 May 27.

Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.新生儿 FcR 在调节含有人 IgG1 Fc 结构域的治疗性蛋白血清半衰期中的重要性：单克隆抗体和 Fc 融合蛋白与人新生儿 FcR 亲和力的比较研究。

J Immunol. 2010 Feb 15;184(4):1968-76. doi: 10.4049/jimmunol.0903296. Epub 2010 Jan 18.

Immunoglobulin Fc domain fusion to apolipoprotein(a) kringle V significantly prolongs plasma half-life without affecting its anti-angiogenic activity.免疫球蛋白 Fc 结构域融合到载脂蛋白（a）kringle V 可显著延长其血浆半衰期，而不影响其抗血管生成活性。

Protein Eng Des Sel. 2013 Jun;26(6):425-32. doi: 10.1093/protein/gzt015. Epub 2013 Apr 9.

Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A.通过融合到葡萄球菌蛋白 A 的 B 结构域来延长单链二价体的半衰期。

Protein Eng Des Sel. 2012 Feb;25(2):81-8. doi: 10.1093/protein/gzr061. Epub 2012 Jan 11.

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice.IgG及多种Fc融合蛋白在小鼠体内的药代动力学特性。

MAbs. 2016;8(1):120-8. doi: 10.1080/19420862.2015.1113360.

Recombinant human lactoferrin-Fc fusion with an improved plasma half-life.具有改善的血浆半衰期的重组人乳铁蛋白-Fc融合蛋白。

Eur J Pharm Sci. 2015 Jan 25;67:136-143. doi: 10.1016/j.ejps.2014.11.005. Epub 2014 Nov 26.

Strategies to extend plasma half-lives of recombinant antibodies.延长重组抗体血浆半衰期的策略。

BioDrugs. 2009;23(2):93-109. doi: 10.2165/00063030-200923020-00003.

引用本文的文献

Prognostic value of elabela peptide on predicting major adverse cardiac events of NSTEMI patients in emergency department.依拉贝拉肽对预测急诊科非ST段抬高型心肌梗死患者主要不良心脏事件的预后价值。

Ir J Med Sci. 2025 Aug 14. doi: 10.1007/s11845-025-04054-8.

[A recombinant adeno-associated virus expressing secretory TGF-β type Ⅱ receptor inhibits triple-negative murine breast cancer 4T1 cell proliferation and lung metastasis in mice].一种表达分泌型转化生长因子-βⅡ型受体的重组腺相关病毒抑制小鼠三阴性乳腺癌4T1细胞增殖及肺部转移

Nan Fang Yi Ke Da Xue Xue Bao. 2024 May 20;44(5):818-826. doi: 10.12122/j.issn.1673-4254.2024.05.03.

Advances in the study of ELABELA in renal physiological functions and related diseases.埃拉贝拉（ELABELA）在肾脏生理功能及相关疾病研究中的进展

Front Pharmacol. 2023 Oct 31;14:1276488. doi: 10.3389/fphar.2023.1276488. eCollection 2023.

Development of HEK293T-produced recombinant receptor-Fc proteins as potential candidates against canine distemper virus.以HEK293T细胞表达的重组受体-Fc蛋白作为抗犬瘟热病毒潜在候选物的研发

Front Vet Sci. 2023 May 5;10:1180673. doi: 10.3389/fvets.2023.1180673. eCollection 2023.

Plasma Levels of Apelinergic System Components in Patients with Chronic and Acute Coronary Syndromes-A Pilot Study.慢性和急性冠状动脉综合征患者血浆中阿片肽系统成分水平的初步研究

J Clin Med. 2021 Sep 26;10(19):4420. doi: 10.3390/jcm10194420.

Plasma levels of Elabela are associated with coronary angiographic severity in patients with acute coronary syndrome.急性冠脉综合征患者中，埃拉贝拉肽的血浆水平与冠状动脉造影严重程度相关。

J Geriatr Cardiol. 2020 Nov 28;17(11):674-679. doi: 10.11909/j.issn.1671-5411.2020.11.004.

The Elabela-APJ axis: a promising therapeutic target for heart failure.Elabela-APJ 轴：心力衰竭有前途的治疗靶点。

Heart Fail Rev. 2021 Sep;26(5):1249-1258. doi: 10.1007/s10741-020-09957-5.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验