Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400013, China; Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, China.
Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 400013, China; Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, China.
Brain Res Bull. 2019 Nov;153:15-23. doi: 10.1016/j.brainresbull.2019.08.004. Epub 2019 Aug 7.
Recent animal studies on heterochronic parabiosis (a technique combining the blood circulation of two animals) have revealed that young blood has a powerful rejuvenating effect on brain aging. Circulating factors, especially growth differentiation factor 11 (GDF11) and C-C motif chemokine 11 (CCL11), may play a key role in this effect, which inspires hope for novel approaches to treating age-related cerebral diseases in humans, such as neurodegenerative and neurovascular diseases. Recently, attempts have begun to translate these astonishing and exciting findings from mice to humans and from bench to bedside. However, increasing reports have shown contradictory data, questioning the capacity of these circulating factors to reverse age-related brain dysfunction. In this review, we summarize the current research on the role of young blood, as well as the circulating factors GDF11 and CCL11, in the aging brain and age-related cerebral diseases. We highlight recent controversies, discuss related challenges and provide a future outlook.
最近关于异时共生（一种将两种动物的血液循环结合在一起的技术）的动物研究表明，年轻的血液对大脑衰老具有强大的抗衰老作用。循环因子，特别是生长分化因子 11（GDF11）和 C-C 基序趋化因子 11（CCL11），可能在这种作用中发挥关键作用，这为治疗人类与年龄相关的大脑疾病，如神经退行性疾病和神经血管疾病，提供了新的方法。最近，人们开始尝试将这些令人惊讶和令人兴奋的发现从老鼠转化到人类，并从实验室转化到临床。然而，越来越多的报告显示出相互矛盾的数据，质疑这些循环因子逆转与年龄相关的大脑功能障碍的能力。在这篇综述中，我们总结了年轻血液以及循环因子 GDF11 和 CCL11 在衰老大脑和与年龄相关的大脑疾病中的作用的最新研究。我们强调了最近的争议，讨论了相关的挑战，并提供了未来的展望。
