Moses S, Barland P
JAMA. 1979 Sep 7;242(10):1039-43.
Patients with systemic lupus erythematosus (SLE) and other connective tissue diseases were surveyed for the presence of antibodies to normal DNA, antibodies to a ribonuclease-insensitive acidic nuclear protein, and immune deposits in normal skin. While 80% of patients with SLE had abnormal values for at least two of these three tests, none of the patients with other connective tissue diseases had more than one abnormal value. The presence of RBC autoantibodies was found along with one of the other abnormal laboratory tests in 76% of patients with SLE, including 14% of patients not found to have two abnormal tests. None of the other patients tested had RBC autoantibodies. These findings suggest that a set of laboratory tests can be constructed as criteria for a diagnosis of SLE that would be as specific as the presently employed American Rheumatism Association criteria.
对系统性红斑狼疮（SLE）患者和其他结缔组织疾病患者进行了调查，检测其是否存在抗正常DNA抗体、抗核糖核酸酶不敏感酸性核蛋白抗体以及正常皮肤中的免疫沉积物。虽然80%的SLE患者这三项检测中至少有两项结果异常，但其他结缔组织疾病患者中没有一人有超过一项异常结果。在76%的SLE患者中，红细胞自身抗体与其他一项异常实验室检测结果同时出现，其中包括14%未发现两项异常检测结果的患者。其他接受检测的患者均未出现红细胞自身抗体。这些发现表明，可以构建一组实验室检测标准用于SLE的诊断，其特异性将与目前采用的美国风湿病协会标准相当。
